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talin 1

Summary

Gene Symbol

TLN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7094

KEGG Gene ID

PubChem

7094

Alliance of Genome Resources

HGNC:11845

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell junction
Cell membrane
Cell projection
Cytoskeleton
Direct protein sequencing
Host-virus interaction
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y490

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell-cell junction assembly	TAS
cell-cell junction assembly	IEA
cell-substrate junction assembly
cell adhesion	IEA
integrin-mediated signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

cell adhesion

cell-cell adhesion

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cortical actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

actin cytoskeleton organization

cortical actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

protein-containing complex assembly [inference]

integrin activation

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction organization [inference]

cell-cell junction assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

integrin activation

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cellular component organization [inference]

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

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GO Term	Evidence Code	PMID
ruffle	ISS
ruffle	IEA
extracellular region	TAS
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
phosphatidylserine binding	IEA
actin binding	IEA
integrin binding	IBA
integrin binding	IPI
integrin binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

vinculin binding

protein domain specific binding [inference]

LIM domain binding

cell adhesion molecule binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

protein-containing complex binding [inference]

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	21894	MGI:1099832

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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