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talin 1

Summary

Gene Symbol

Tln1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21894

KEGG Gene ID

PubChem

21894

Alliance of Genome Resources

MGI:1099832

Annotation

Keyword

3D-structure
Acetylation
Cell junction
Cell membrane
Cell projection
Coiled coil
Cytoplasm
Cytoskeleton
Phosphoprotein
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q0V930
Q3UHS6
P26039
Q80TM2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell-substrate junction assembly	IMP
cell adhesion	IEA
integrin-mediated signaling pathway	IMP
actin cytoskeleton organization	IBA
cortical actin cytoskeleton organization	IMP

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

cell adhesion

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cortical actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

actin cytoskeleton organization

cortical actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cellular component assembly [inference]

cell junction assembly

cell-substrate junction assembly

protein-containing complex assembly [inference]

integrin activation

cell junction organization [inference]

cell junction assembly

cell-substrate junction assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

integrin activation

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
ruffle	ISS
ruffle	IEA
cytoplasm	IBA
cytoplasm	IEA
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

anchoring junction

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding	IMP
actin binding	IEA
integrin binding	ISO
integrin binding	IMP
integrin binding	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

vinculin binding

protein domain specific binding [inference]

LIM domain binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

protein-containing complex binding [inference]

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

talin

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin binding
actin filament binding
cytoskeleton organization
integrin binding
structural constituent of cytoskeleton

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InterPro
Alpha-catenin/vinculin-like superfamily
Band 4.1 domain
FERM central domain
FERM conserved site
FERM domain
FERM superfamily, second domain
FERM/acyl-CoA-binding protein superfamily
I/LWEQ domain superfamily
I/LWEQ domain
PH-like domain superfamily

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	7094	HGNC:11845

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements