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Talin-1

Summary

UniProt ID: P26039
Gene Symbol: Tln Tln1
Gene ID: 21894
Organism: Mus musculus (house mouse)

External Links

GlyGen: P26039
PubChem: P26039
The O-GlcNAc Database: P26039
RaftProt: P26039
O-GlcNAcAtlas: P26039
Re-Glyco: P26039

Annotation

Keyword: 3D-structure Acetylation Cell junction Cell membrane Cell projection Cytoskeleton Phosphoprotein Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
cell-substrate junction assembly	IMP	PMID
integrin-mediated signaling pathway	IMP	PMID
actin cytoskeleton organization	IBA	GO_REF
cortical actin cytoskeleton organization	IMP	PMID
integrin activation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

cell adhesion [inference]

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cortical actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

actin cytoskeleton organization

cortical actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly

protein-containing complex assembly [inference]

integrin activation

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

integrin activation

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
ruffle	ISS	GO_REF
ruffle	IEA	GO_REF
cytoplasm	IBA	GO_REF
cytosol	ISO	GO_REF
cytosol	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

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GO Term	Evidence Code	Reference
phosphatidylserine binding	IMP	PMID
integrin binding	ISO	GO_REF GO_REF
integrin binding	IMP	PMID
integrin binding	IBA	GO_REF
integrin binding	IEA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

vinculin binding

protein domain specific binding [inference]

LIM domain binding

cell adhesion molecule binding [inference]

integrin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

protein-containing complex binding [inference]

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPASPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGDPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPNPDLKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	PubMed ID	GlyTouCan ID	Source
927		G49108TO	GlyGen
2098	29187734 30016717 36288343 37453647 37507081 39627609 39927985	G49108TO	GlyGen The O-GlcNAc Database
2169		G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
GRB2:SOS provides linkage to MAPK signaling for Integrins	Mus musculus
Integrin signaling	Mus musculus
MAP2K and MAPK activation	Mus musculus
Platelet degranulation	Mus musculus
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Mus musculus
Smooth Muscle Contraction	Mus musculus
p130Cas linkage to MAPK signaling for integrins	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements