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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

complement C1r

Summary

Gene Symbol

C1R

Organism

Homo sapiens (human)

External Links

NCBI Gene

715

KEGG Gene ID

PubChem

715

Alliance of Genome Resources

HGNC:1246

Annotation

Keyword

3D-structure
Autocatalytic cleavage
Calcium
Complement pathway
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Ehlers-Danlos syndrome
Glycoprotein
Hydroxylation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A3B3ISR2	Complement component 1 subcomponent r
P00736	Complement component 1 subcomponent r
B4DPQ0	Complement component 1 subcomponent r

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
proteolysis	IEA
immune response	TAS
complement activation	IEA
complement activation, classical pathway	NAS
complement activation, classical pathway	TAS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	NAS
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

complement component C1 complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase activity	EXP
serine-type endopeptidase activity	TAS
serine-type endopeptidase activity	IDA
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannan-binding lectin serine

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
calcium ion binding
complement activation, classical pathway
complement activation
hydrolase activity
immune system process
metal ion binding
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Peptidase S1A, complement C1r/C1S/mannan-binding
Serine proteases, trypsin domain
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080986	Ehlers-Danlos syndrome periodontal type 1	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	50909	MGI:1355313
Mus musculus	667277	MGI:3779804

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026