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Complement C1r subcomponent

Summary

UniProt ID: P00736
Gene Symbol: C1R
Gene ID: 715
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011276

GlyConnect

Complement c1r subcomponent

GlyGen

P00736

PubChem

P00736

The Human Metabolome Database

HMDBP07480

Re-Glyco

P00736

Annotation

Keyword: 3D-structure Autocatalytic cleavage Complement pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Ehlers-Danlos syndrome Glycoprotein Hydroxylation Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Sushi

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
immune response	TAS	PMID
complement activation, classical pathway	NAS	PMID
complement activation, classical pathway	TAS	Reactome
complement activation, classical pathway	IDA	PMID PMID PMID PMID PMID PMID PMID PMID
zymogen activation	IDA	PMID PMID PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	NAS	PMID PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

complement component C1 complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
serine-type endopeptidase activity	EXP	PMID
serine-type endopeptidase activity	TAS	PMID
serine-type endopeptidase activity	IDA	PMID PMID PMID PMID PMID PMID
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
125	N-linked (GlcNAc...) asparagine	16335952 29311313 29391424 29741879 37074911	G39595FH G64394MX G15169WU G11629QQ G81263BG G22310AV G59536GA G02030ZB G08918WF G00912UN G48414YA G84452RH G92050GC G92275SC	UniProt GlyGen GlyConnect
221	N-linked (GlcNAc...) asparagine	16335952 24190977 29391424 29671580 29741879 37074911	G64394MX G93656SY G34617SM G41882MT G27947YN G98611JV G47748JZ G00912UN G48414YA G78790NZ G27058EU G59626AS G80920RR G45504EY G37399XV G62765YT G10486CT G95865ZB G31852PQ G72787SB G41247ZX G57776ZU G57317CE	UniProt GlyGen GlyConnect
514	N-linked (GlcNAc...) asparagine	16335952 19159218 24279413 29671580 29741879 37074911	G70232NH G06247RL G57776ZS G77669RF G90382BL G63980BQ G04854VP G94470IW G40834TG G45395BF G59324HL G20706XG G40926MX G43223CG G40574BA G08918WF G00912UN G42358LZ G48414YA G61256FT G27126ED G04657PL G27058EU G10488MI G60033FS G41071NU G59626AS	GlycoProtDB UniProt GlyGen GlyConnect
581	N-linked (GlcNAc...) asparagine	11823416		UniProt GlyGen