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MIRAGE

ectonucleoside triphosphate diphosphohydrolase 8

Summary

Gene Symbol

Entpd8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72090

KEGG Gene ID

PubChem

72090

Alliance of Genome Resources

MGI:1919340

Annotation

Keyword

ATP-binding
Alternative splicing
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K0L2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
nucleoside monophosphate biosynthetic process	IDA
nucleoside diphosphate biosynthetic process	IDA
nucleoside diphosphate catabolic process	IBA
ribonucleoside diphosphate catabolic process	ISO
ribonucleoside diphosphate catabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate biosynthetic process

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate biosynthetic process

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate biosynthetic process

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

nucleoside monophosphate biosynthetic process

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate biosynthetic process

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate biosynthetic process [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
apyrase activity	ISO
apyrase activity	IDA
apyrase activity	IEA
GDP phosphatase activity	IBA
ATP binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

apyrase activity

nucleoside diphosphate phosphatase activity

ribonucleoside triphosphate phosphatase activity

ATP hydrolysis activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ectonucleoside triphosphate diphosphohydrolase

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying 1 entry
InterPro
Nucleoside phosphatase GDA1/CD39

Rhea

H₂O + a ribonucleoside 5'-triphosphate

H⁺ + phosphate + a ribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

H₂O + a 2'-deoxyribonucleoside 5'-triphosphate

H⁺ + phosphate + a 2'-deoxyribonucleoside 5'-phosphate

Enzyme

3.6.1.5

PMID

15576788

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	613267	RGD:1561793
Homo sapiens	377841	HGNC:24860

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026