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complement C8 alpha chain

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

731

PubChem

731

Alliance of Genome Resources

HGNC:1352

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Complement alternate pathway
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Target cell membrane
Transmembrane beta strand

Proteins

Displaying 1 entry
UniProt	Protein Name
P07357	Complement component 8 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
immune response	TAS	6771072
complement activation	IDA	12413696
complement activation	IBA
complement activation, alternative pathway	IEA
complement activation, classical pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
membrane attack complex	IDA	12413696 22832194
membrane attack complex	IBA
membrane attack complex	IPI	30552328
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
complement binding	IEA
protein binding	IPI	32296183
protein-containing complex binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

complement binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060301	type I complement component 8 deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 92** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Panthera leo	122227381		PANLE10900
Ursus americanus	123795382		URSAM25768

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements