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MIRAGE
Complement component C8 alpha chain

Summary
UniProt ID
P07357
Gene Symbol
  • C8A
Gene ID
731
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011419
GlyConnect
GlyGen
P07357
PubChem
P07357
Re-Glyco
P07357
Annotation
Keyword
  • 3D-structure
  • Cleavage on pair of basic residues
  • Complement alternate pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Membrane attack complex
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Target cell membrane
  • Transmembrane beta strand
Gene Ontology (GO)
Displaying all 7 entries
GO Term
extracellular region
extracellular space
plasma membrane
membrane attack complex
membrane
extracellular exosome
blood microparticle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
complement binding
protein-containing complex binding
Site Annotations
Displaying 1 entry
Position Description
43 Not glycosylated
Annotation information from UniProt.
Sequence
MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
33
43
44 C-linked (Man) tryptophan
437 N-linked (GlcNAc...) asparagine
542 C-linked (Man) tryptophan
545 C-linked (Man) tryptophan
548 C-linked (Man) tryptophan
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Regulation of Complement cascade Homo sapiens
Terminal pathway of complement Homo sapiens
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0060301 type I complement component 8 deficiency
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025