GlyCosmos Portal

Submissions

Terminal pathway of complement

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-166665

PubChem

R-HSA-166665

Description

After cleavage of C5, C5b undergoes conformational changes and exposes a binding site for C6. C5b6 binds C7 resulting in the exposure of membrane binding sites and incorporation into target membranes. The membrane-bound C5b-7 complex can then bind C8. C5b-8 acts as a polymerizing agent for C9. The first C9 bound to C5b-8 undergoes major structural changes enabling formation of an elongated molecule and allows binding of additional C9 molecules and insertion of C9 cylinders into the target membrane. The number of C9 molecules varies from 1-12 in the membrane, although polymers containing up to fifteen C9 molecules are also possible.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01031	Complement C5	C5 CPAMD4	view
P02748	Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]	C9	view
P07357	Complement component C8 alpha chain	C8A	view
P07358	Complement component C8 beta chain	C8B hCG_23458	view
P10643	Complement component C7	C7	view
P10909	Clusterin	AAG4 APOJ CLI CLU KUB1	view
P13671	Complement component C6	C6	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.