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Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

Summary

UniProt ID: P02748
Gene Symbol: C9
Gene ID: 735
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011309

GlyConnect

Complement component C9

GlyGen

P02748

PubChem

P02748

RaftProt

P02748

Re-Glyco

P02748

Annotation

Keyword: 3D-structure Age-related macular degeneration Complement alternate pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Glycoprotein Membrane attack complex Phosphoprotein Proteomics identification Reference proteome Secreted Signal Target cell membrane Transmembrane beta strand

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
cell killing	IDA	PMID PMID
complement activation	IDA	PMID PMID PMID PMID PMID PMID
complement activation	IBA	GO_REF
complement activation, alternative pathway
complement activation, classical pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

cellular process [inference]

cell killing

killing of cells of another organism

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID PMID PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID PMID
extracellular region	IEA	GO_REF
membrane attack complex	IDA	PMID PMID PMID PMID PMID PMID PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

other organism cell membrane

blood microparticle

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACEISKQKISEGLPALEFPNEK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
24		30459171	G43417UB	GlyGen
26		30459171	G58001LT	GlyGen
32		30459171	G43417UB G29068FM	GlyGen
48	C-linked (Man) tryptophan	10551839		UniProt GlyGen
51	C-linked (Man) tryptophan; partial	10551839		UniProt GlyGen
123		23090970		GlyGen
258		30459171	G43417UB G29068FM	GlyGen
277	N-linked (GlcNAc...) asparagine	16335952 19159218 23090970 29671580 29741879 30552328 37074911 4055801	G94470IW G45395BF G26330YA G10846ZT G40574BA G82830MN G08918WF G00912UN G48414YA G11911BT G27058EU G72747WU G70619PT G06356OH G59626AS G10486CT G95865ZB G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
415	N-linked (GlcNAc...) (complex) asparagine	14760718 16263699 16335952 19139490 19159218 23090970 29391424 29671580 29741879 30552328 37074911 4055801	G64751KD G11101UV G56518TU G70232NH G14547CB G81124ET G70888PK G06247RL G57776ZS G75418YA G99668VU G27947YN G37692EO G04854VP G94470IW G92135MA G98611JV G40834TG G22310AV G45395BF G85554PZ G40926MX G26330YA G10846ZT G40574BA G82830MN G78787DI G08918WF G75983OB G00912UN G48414YA G36442WJ G27126ED G04657PL G27058EU G84452RH G46902YN G72747WU G70619PT G06356OH G59626AS G45504EY G10486CT G95865ZB G22572EH G57776ZU G57317CE G28681TP G54010QB G98129XB	GlycoProtDB UniProt GlyGen GlyConnect
518				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Regulation of Complement cascade	Homo sapiens
Terminal pathway of complement	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2559	opiate dependence	Alliance of Genome Resources
DOID:0110027	age related macular degeneration 15	Alliance of Genome Resources
DOID:0060303	complement component 9 deficiency	Alliance of Genome Resources

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Acknowledgements