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Complement C5

Summary

UniProt ID

P01031

Gene Symbol

C5
CPAMD4

Gene ID

727

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011294

GlyConnect

Complement C5

GlyGen

P01031

PubChem

P01031

Re-Glyco

P01031

Annotation

Keyword: 3D-structure Cleavage on pair of basic residues Complement alternate pathway Direct protein sequencing Disease variant Disulfide bond Glycoprotein Inflammatory response Membrane attack complex Proteomics identification Reference proteome Secreted Signal Target cell membrane

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
chemotaxis	TAS	PMID
chemotaxis	IEA	GO_REF
inflammatory response	TAS	PMID
inflammatory response	IEA	GO_REF GO_REF
complement activation, alternative pathway	IDA	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

activation of immune response [inference]

complement activation [inference]

immune response [inference]

humoral immune response [inference]

complement activation [inference]

innate immune response [inference]

cellular process [inference]

cell killing [inference]

killing of cells of another organism

signal transduction [inference]

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation [inference]

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

regulation of cellular process [inference]

signal transduction [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID PMID
extracellular region	TAS	PMID Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF
membrane attack complex	IDA	PMID PMID PMID PMID PMID PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

other organism cell membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
endopeptidase inhibitor activity	IEA	GO_REF
signaling receptor binding	TAS	PMID PMID
chemokine activity	TAS	PMID
chemokine activity	IDA	PMID PMID PMID PMID PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

chemokine activity

cytokine receptor binding [inference]

chemokine receptor binding [inference]

chemokine activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity [inference]

chemokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity [inference]

chemokine activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
741	N-linked (GlcNAc...) asparagine	16335952 18536718 23090970 29391424 37074911	G56518TU G38663NM G70232NH G06247RL G57776ZS G77669RF G27947YN G04854VP G94470IW G45395BF G40926MX G26330YA G40574BA G08918WF G00912UN G92551JA G25418HZ G27058EU G84452RH G59626AS G90659AW G10486CT G95865ZB	GlycoProtDB UniProt GlyGen GlyConnect
911	N-linked (GlcNAc...) asparagine	16335952 18536718 21217642		UniProt GlyGen
1115	N-linked (GlcNAc...) asparagine	29671580 37074911	G02030ZB G12580WI G00912UN	UniProt GlyGen GlyConnect
1630	N-linked (GlcNAc...) asparagine	16335952 29391424 37074911	G00912UN G48414YA G06356OH	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Activation of C3 and C5	Homo sapiens
G alpha (i) signalling events	Homo sapiens
Peptide ligand-binding receptors	Homo sapiens
Regulation of Complement cascade	Homo sapiens
Terminal pathway of complement	Homo sapiens

Disease

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Alliance of Genome Resources
DOID:1227	neutropenia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:552	pneumonia	Alliance of Genome Resources
DOID:8158	complement component 5 deficiency	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements