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calcium voltage-gated channel subunit alpha1 B

Summary

Gene Symbol

CACNA1B

Organism

Homo sapiens (human)

External Links

NCBI Gene

774

PubChem

774

Alliance of Genome Resources

HGNC:1389

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Calcium channel
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Intellectual disability
Metal-binding
Methylation
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00975	Brain calcium channel III Calcium channel, L type, alpha-1 polypeptide isoform 5 Voltage-gated calcium channel subunit alpha Cav2.2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chemical synaptic transmission	TAS	9030575
chemical synaptic transmission	IBA
modulation of chemical synaptic transmission	IDA	23376566
calcium ion import across plasma membrane	IBA
response to amyloid-beta	IDA	23376566

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
voltage-gated calcium channel complex	IBA
neuronal cell body	IBA
synapse	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex [inference]

voltage-gated calcium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IC	23376566
voltage-gated calcium channel activity	IDA	1321501
voltage-gated calcium channel activity	IMP	25296916
calcium ion binding	IEA
protein binding	IPI	11438518 15728831 20195357

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity

high voltage-gated calcium channel activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent N-type calcium channel subunit alpha-1B

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
chemical synaptic transmission
high voltage-gated calcium channel activity
metal ion binding
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 5** entries
InterPro
Ion transport domain
Voltage-dependent L-type calcium channel, IQ-associated domain
Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Voltage-dependent calcium channel, alpha-1 subunit
Voltage-dependent channel domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050214	Lambert-Eaton myasthenic syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 107** of **107** in total

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Species	Gene ID	Orthologous MAtrix
Vombatus ursinus	114034332	VOMUR11345
Podarcis muralis	114588906	PODMU25009
Strigops habroptila	115617074	STRHB18029
Corvus moneduloides	116454233	CORMO10760
Chelonoidis abingdonii	116816175	CHEAB14524
Rhinolophus ferrumequinum	117032070	RHIFE21370
Balaenoptera musculus	118897088	BALMU14235