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MIRAGE

dihydrolipoamide S-succinyltransferase

Summary

Gene Symbol

Dlst

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

78920

KEGG Gene ID

PubChem

78920

Alliance of Genome Resources

MGI:1926170

Annotation

Keyword

Acetylation
Acyltransferase
Alternative splicing
Direct protein sequencing
Lipoyl
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D2G2	2-oxoglutarate dehydrogenase complex component E2 Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex E2K

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
tricarboxylic acid cycle	ISS
tricarboxylic acid cycle	ISO
tricarboxylic acid cycle	IMP
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

catabolic process [inference]

amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule catabolic process [inference]

carboxylic acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

amino acid metabolic process [inference]

amino acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process

2-oxoglutarate decarboxylation to succinyl-CoA

carboxylic acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

small molecule catabolic process [inference]

carboxylic acid catabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IEA
nucleoplasm	ISO
nucleoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

alpha-ketoacid dehydrogenase complex [inference]

transferase complex [inference]

cellular anatomical structure [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
dihydrolipoyllysine-residue succinyltransferase activity	ISS
dihydrolipoyllysine-residue succinyltransferase activity	ISO
dihydrolipoyllysine-residue succinyltransferase activity	IBA
dihydrolipoyllysine-residue succinyltransferase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

succinyltransferase activity [inference]

S-succinyltransferase activity [inference]

dihydrolipoyllysine-residue succinyltransferase activity

catalytic activity, acting on a protein [inference]

dihydrolipoyllysine-residue succinyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1743	HGNC:2911
Rattus norvegicus	299201	RGD:1359615

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026