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MIRAGE
dual oxidase 2

Summary
Gene Symbol
  • Duox2
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
79107
KEGG Gene ID
PubChem
79107
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Calcium
  • Cell junction
  • Cell membrane
  • Disulfide bond
  • FAD
  • Glycoprotein
  • Hydrogen peroxide
  • Metal-binding
  • NADP
  • Reference proteome
  • Repeat
  • Signal
  • Thyroid hormones biosynthesis
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
A6HPS6
Q9ES45
  • Large NOX 2
  • Long NOX 2
  • NADH/NADPH thyroid oxidase THOX2
  • Thyroid oxidase 2
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 26 in total
GO Term Evidence Code PMID
thyroid hormone generation
thyroid hormone generation
defense response
response to oxidative stress
fertilization
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Dual oxidase
Functional Category
  • P: Inorganic ion transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Displaying all 8 entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity
Displaying entries 1 - 10 of 13 in total
InterPro
Dual oxidase, peroxidase domain
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type
Ortholog
Displaying all 4 entries
Species Gene ID Alliance of Genome Resources
171608 WB:WBGene00000253
186188 WB:WBGene00018771
33477 FB:FBgn0283531
50506 HGNC:13273
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026