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Guidelines

MIRAGE

NAD(P)H oxidase (H2O2-forming)

Summary

Gene Symbol

duox-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

186188

KEGG Gene ID

PubChem

186188

Alliance of Genome Resources

WB:WBGene00018771

Annotation

Keyword

Calcium
FAD
Glycoprotein
Heme
Hydrogen peroxide
NADP
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O01795

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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2

3

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GO Term	Evidence Code	PMID
defense response	IBA
response to oxidative stress	IEA
post-embryonic animal morphogenesis	IEA
post-embryonic body morphogenesis	IMP
molting cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

multicellular organismal process [inference]

molting cycle

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis

post-embryonic body morphogenesis

body morphogenesis [inference]

post-embryonic body morphogenesis

anatomical structure development [inference]

cuticle development

collagen and cuticulin-based cuticle development [inference]

cuticle development involved in collagen and cuticulin-based cuticle molting cycle

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response

defense response to bacterium

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
membrane	IEA
NADPH oxidase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical structure [inference]

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
peroxidase activity	IEA
calcium ion binding	IEA
NAD(P)H oxidase H2O2-forming activity	IBA
NAD(P)H oxidase H2O2-forming activity	IEA
superoxide-generating NAD(P)H oxidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nadph oxidase

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
oxidoreductase activity
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

Displaying **all 7** entries
InterPro
Cytochrome b245, heavy chain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Riboflavin synthase-like beta-barrel

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	99439	MGI:2139422
Rattus norvegicus	79107	RGD:628761
Rattus norvegicus	266807	RGD:628760
Drosophila melanogaster	33477	FB:FBgn0283531
Homo sapiens	53905	HGNC:3062
Homo sapiens	50506	HGNC:13273

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026