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MIRAGE

UDP-glucuronate decarboxylase 1

Summary

Gene Symbol

UXS1

Aliases

FLJ23591
SDR6E1
UGD
short chain dehydrogenase/reductase family 6E, member 12

Organism

Homo sapiens (human)

External Links

NCBI Gene

80146

HGNC

17729

KEGG Gene ID

hsa:80146

PubChem

80146

Alliance of Genome Resources

HGNC:17729

JoGo

UXS1

TogoVar

UXS1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Decarboxylase
Disease variant
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
NAD
Phosphoprotein
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8NBZ7	UDP-glucuronate decarboxylase 1
B3KV61	UDP-glucuronate decarboxylase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycosaminoglycan biosynthetic process	IDA
UDP-D-xylose biosynthetic process	IDA
UDP-D-xylose biosynthetic process	IEA
D-xylose metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

pentose metabolic process [inference]

D-xylose metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

pentose metabolic process [inference]

D-xylose metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

UDP-D-xylose metabolic process [inference]

UDP-D-xylose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-D-xylose biosynthetic process

Displaying entries **1 - 5** of 10 in total

1

2

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Last »
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IDA
Golgi membrane	IEA
cytoplasm	IBA
endoplasmic reticulum membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
identical protein binding	IPI
protein homodimerization activity	IDA
UDP-glucuronate decarboxylase activity	IDA
UDP-glucuronate decarboxylase activity	IBA
UDP-glucuronate decarboxylase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

UDP-glucuronate decarboxylase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

NAD+ binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Udp-glucuronic acid decarboxylase

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
D-xylose metabolic process
NAD+ binding
UDP-D-xylose biosynthetic process
UDP-glucuronate decarboxylase activity
carboxy-lyase activity

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
NAD(P)-binding domain
UDP-glucuronic acid decarboxylase

KEGG BRITE Database

Orthology

K08678

Name

UDP-glucuronate decarboxylase [EC:4.1.1.35]

References

Rhea

H⁺ + UDP-α-D-glucuronate

CO₂ + UDP-α-D-xylose

Enzyme

4.1.1.35

PMID

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	67883	MGI:1915133
Rattus norvegicus	246232	RGD:628680
Danio rerio	192315	ZFIN:ZDB-GENE-020419-37
Xenopus tropicalis	448599	Xenbase:XB-GENE-997577

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026