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tyrosylprotein sulfotransferase 1

Summary

Gene Symbol

TPST1

Aliases

TANGO13A
transport and golgi organization 13 homolog A (Drosophila)

Organism

Homo sapiens (human)

External Links

NCBI Gene

8460

HGNC

12020

KEGG Gene ID

hsa:8460

PubChem

8460

Alliance of Genome Resources

HGNC:12020

JoGo

TPST1

TogoVar

TPST1

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60507	Tyrosylprotein sulfotransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidyl-tyrosine sulfation	TAS
post-translational protein modification	IDA
3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
3'-phosphoadenosine 5'-phosphosulfate metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

sulfation [inference]

protein sulfation [inference]

peptidyl-tyrosine sulfation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine nucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine nucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein sulfation [inference]

peptidyl-tyrosine sulfation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine sulfation

post-translational protein modification

macromolecule modification [inference]

protein modification process [inference]

protein sulfation [inference]

peptidyl-tyrosine sulfation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine sulfation

post-translational protein modification

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine nucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein sulfation [inference]

peptidyl-tyrosine sulfation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine sulfation

post-translational protein modification

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleoside bisphosphate metabolic process [inference]

ribonucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine nucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

purine nucleoside bisphosphate metabolic process [inference]

purine ribonucleoside bisphosphate metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

3'-phosphoadenosine 5'-phosphosulfate metabolic process

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IBA
Golgi apparatus	IEA
Golgi lumen
trans-Golgi network
membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-tyrosine sulfotransferase activity	EXP
protein-tyrosine sulfotransferase activity	TAS
protein-tyrosine sulfotransferase activity	IDA
protein-tyrosine sulfotransferase activity	IBA
protein-tyrosine sulfotransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity [inference]

protein-tyrosine sulfotransferase activity

catalytic activity, acting on a protein [inference]

protein-tyrosine sulfotransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein-tyrosine sulfotransferase A

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
protein-tyrosine sulfotransferase activity
transferase activity

Displaying **all 2** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Protein-tyrosine sulfotransferase-like

Human Protein Atlas

ENSG00000169902

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01021

Name

protein-tyrosine sulfotransferase [EC:2.8.2.20]

References

Rhea

RHEA:16801

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

2.8.2.20

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22021	MGI:1298231
Rattus norvegicus	288617	RGD:1308473
Caenorhabditis elegans	176684	WB:WBGene00013737
Drosophila melanogaster	32312	FB:FBgn0086674
Danio rerio	30677	ZFIN:ZDB-GENE-000210-10

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements