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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Protein-tyrosine sulfotransferase 1
Summary
- UniProt ID
- O60507
- Gene Symbol
-
- TPST1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O60507
- The Human Metabolome Database
- HMDBP11981
- The O-GlcNAc Database
- O60507
Annotation
- Keyword
-
- 3D-structure
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Reference proteome
- Signal-anchor
- Transferase
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| post-translational protein modification |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| membrane |
| GO Term |
|---|
| protein homodimerization activity |
| protein-tyrosine sulfotransferase activity |
Sequence
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRVYKGEFQLPDFLKEKPQTEQVE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 44 |
|
|||
| 46 |
|
|||
| 47 |
|
|||
| 49 |
|
|||
| 50 |
|
|||
| 53 |
|
|||
| 60 | N-linked (GlcNAc...) asparagine |
|
||
| 197 |
|
|||
| 199 |
|
|||
| 262 | N-linked (GlcNAc...) asparagine |
G57321FI
G07246CJ
G22572EH
G84225JN
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cytosolic sulfonation of small molecules | Homo sapiens |
| Defective F8 sulfation at Y1699 | Homo sapiens |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080199 | colorectal carcinoma | |
| DOID:13189 | gout | |
| DOID:1324 | lung cancer | |
| DOID:1325 | bronchus cancer | |
| DOID:162 | cancer | |
| DOID:3683 | lung benign neoplasm | |
| DOID:3904 | bronchus carcinoma | |
| DOID:3905 | lung carcinoma | |
| DOID:5672 | large intestine cancer | |
| DOID:9256 | colorectal cancer |
