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isoleucine--tRNA ligase ILS1

Summary

Gene Symbol

ILS1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852202

KEGG Gene ID

PubChem

852202

Alliance of Genome Resources

SGD:S000000172

Annotation

Keyword

3D-structure
ATP-binding
Aminoacyl-tRNA synthetase
Cytoplasm
Direct protein sequencing
Isopeptide bond
Phosphoprotein
Protein biosynthesis
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P09436	Isoleucyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
tRNA aminoacylation for protein translation	IEA
isoleucyl-tRNA aminoacylation	IDA
isoleucyl-tRNA aminoacylation	IBA
isoleucyl-tRNA aminoacylation	IEA
aminoacyl-tRNA metabolism involved in translational fidelity	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

isoleucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

isoleucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

isoleucyl-tRNA aminoacylation

biological regulation [inference]

regulation of biological quality [inference]

regulation of translational fidelity [inference]

aminoacyl-tRNA metabolism involved in translational fidelity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
tRNA binding	IEA
nucleotide binding	IEA
aminoacyl-tRNA deacylase activity	IEA
aminoacyl-tRNA ligase activity	IEA
isoleucine-tRNA ligase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA deacylase activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity

isoleucine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA deacylase activity

aminoacyl-tRNA ligase activity

isoleucine-tRNA ligase activity

deacylase activity [inference]

aminoacyl-tRNA deacylase activity

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

mRNA binding [inference]

sequence-specific mRNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytosol	PMID:7619074

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	105148	MGI:2145219

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Last updated: April 6, 2026

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