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MIRAGE

isocitrate dehydrogenase (NAD(+)) IDH1

Summary

Gene Symbol

IDH1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

855691

KEGG Gene ID

sce:YNL037C

PubChem

855691

Alliance of Genome Resources

SGD:S000004982

Annotation

Keyword

3D-structure
Allosteric enzyme
Direct protein sequencing
Magnesium
Manganese
Metal-binding
Mitochondrion
NAD
Oxidoreductase
RNA-binding
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P28834	Isocitric dehydrogenase NAD(+)-specific ICDH

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
tricarboxylic acid cycle	TAS
tricarboxylic acid cycle	IDA
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA
isocitrate metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

L-glutamate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

primary metabolic process [inference]

tricarboxylic acid cycle

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process [inference]

L-glutamate biosynthetic process

L-amino acid metabolic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

L-glutamate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

L-glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

L-glutamate biosynthetic process

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

L-glutamate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process [inference]

L-glutamate biosynthetic process

L-amino acid metabolic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

dicarboxylic acid biosynthetic process [inference]

L-glutamate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-glutamine family amino acid biosynthetic process [inference]

L-glutamate biosynthetic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
mitochondrion	RCA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical structure [inference]

cytosol

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
RNA binding
isocitrate dehydrogenase (NAD+) activity	RCA
isocitrate dehydrogenase (NAD+) activity	IDA
isocitrate dehydrogenase (NAD+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
isocitrate dehydrogenase (NAD+) activity
isocitrate metabolic process
magnesium ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NAD-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
isocitrate dehydrogenase complex (NAD+)	PMID:16884682
mitochondrion	PMID:16823961 PMID:24769239
mitochondrial matrix	PMID:8626605
mitochondrial nucleoid	PMID:15692048

Rhea

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	243996	MGI:2142174
Rattus norvegicus	94173	RGD:621881
Homo sapiens	3421	HGNC:5386
Homo sapiens	3420	HGNC:5385

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026