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nucleotide diphosphatase/phosphodiesterase NPP2

Summary

Gene Symbol

NPP2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856699

PubChem

856699

Alliance of Genome Resources

SGD:S000000742

Annotation

Keyword

Glycoprotein
Hydrolase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P39997

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	IEA
nucleoside triphosphate metabolic process	IMP	16278456
nucleoside triphosphate metabolic process	IBA
organophosphate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	HDA	26928762
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phosphodiesterase I activity	IEA
zinc ion binding	RCA	30358795
hydrolase activity	IEA
ribonucleoside triphosphate phosphatase activity	IMP	16278456
ribonucleoside triphosphate phosphatase activity	IGI	16278456

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phosphodiesterase I activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity

nucleoside triphosphate diphosphatase activity

8-oxo-(d)RTP hydrolase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ectonucleotide pyrophosphatase/phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
nucleoside triphosphate diphosphatase activity

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
endoplasmic reticulum	PMID:26928762

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	5167	ZFIN:ZDB-GENE-040724-172
Xenopus tropicalis	5168	Xenbase:XB-GENE-1016186
Xenopus tropicalis	5169	Xenbase:XB-GENE-1012338
Danio rerio	18605	ZFIN:ZDB-GENE-040724-172
Xenopus tropicalis	18606	Xenbase:XB-GENE-1016186
Xenopus tropicalis	22875	Xenbase:XB-GENE-1013025
Xenopus tropicalis	54410	Xenbase:XB-GENE-1012338
Danio rerio	59084	ZFIN:ZDB-GENE-041014-10
Danio rerio	83965	ZFIN:ZDB-GENE-041014-10
Xenopus tropicalis	84050	Xenbase:XB-GENE-1016186

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Acknowledgements