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nucleotide diphosphatase/phosphodiesterase NPP2

Summary

Gene Symbol

NPP2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856699

KEGG Gene ID

PubChem

856699

Alliance of Genome Resources

SGD:S000000742

Annotation

Keyword

Glycoprotein
Hydrolase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P39997

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	IEA
nucleoside triphosphate metabolic process	IMP
nucleoside triphosphate metabolic process	IBA
organophosphate metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	HDA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
phosphodiesterase I activity	IEA
zinc ion binding	RCA
hydrolase activity	IEA
ribonucleoside triphosphate phosphatase activity	IMP
ribonucleoside triphosphate phosphatase activity	IGI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

phosphodiesterase I activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phosphodiesterase I activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pyrophosphatase/phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
nucleoside triphosphate diphosphatase activity
nucleoside triphosphate metabolic process
ribonucleoside triphosphate phosphatase activity

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
endoplasmic reticulum	PMID:26928762

Ortholog

Displaying entries **1 - 10** of 25 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	18605	MGI:97370
Mus musculus	18606	MGI:1321390
Mus musculus	209558	MGI:2143702
Mus musculus	224794	MGI:2682634
Mus musculus	320981	MGI:2445171
Mus musculus	83965	MGI:1933830
Rattus norvegicus	303729	RGD:1359324
Rattus norvegicus	316249	RGD:1359199
Rattus norvegicus	54410	RGD:708511
Rattus norvegicus	84050	RGD:69298

GlyTouCan

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements