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MIRAGE
TNF superfamily member 11
Summary
- Gene Symbol
-
- TNFSF11
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cytokine
- Cytoplasm
- Developmental protein
- Differentiation
- Disease variant
- Glycoprotein
- Osteopetrosis
- Proteomics identification
- Receptor
- Reference proteome
- Secreted
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q5T9Y4 |
|
| O14788 |
|
| Q54A98 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II |
|
|
| ossification |
|
|
| osteoclast proliferation |
|
|
| monocyte chemotaxis |
|
|
| immune response |
|
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of transport [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| extracellular region |
|
|
| obsolete extracellular space |
|
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor binding |
|
|
| cytokine activity |
|
|
| cytokine activity |
|
|
| cytokine activity |
|
|
| cytokine activity |
|
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Gamma-glutamyl hydrolase A
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
- V: Defense mechanisms
| Gene Ontology |
|---|
| gamma-glutamyl-peptidase activity |
| hydrolase activity |
| omega peptidase activity |
| tetrahydrofolylpolyglutamate metabolic process |
| InterPro |
|---|
| Class I glutamine amidotransferase-like |
| Peptidase C26, gamma-glutamyl hydrolase |
| Peptidase C26 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110943 | autosomal recessive osteopetrosis 2 | |
| DOID:11476 | osteoporosis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources |
|---|---|---|
| 21943 | MGI:1100089 | |
| 117516 | RGD:620784 |
