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MIRAGE
Tumor necrosis factor ligand superfamily member 11
Summary
- UniProt ID
- O14788
- Gene Symbol
- OPGL RANKL TNFSF11 TRANCE
- Gene ID
- 8600
- Organism
- Homo sapiens (human)
External Links
- PubChem
- O14788
- The Human Metabolome Database
- HMDBP02409
- Re-Glyco
- O14788
Annotation
- Keyword
- 3D-structure Alternative splicing Cell membrane Cytokine Cytoplasm Developmental protein Differentiation Disease variant Glycoprotein Osteopetrosis Proteomics identification Receptor Reference proteome Secreted Signal-anchor Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| ossification |
|
|
| osteoclast proliferation |
|
|
| monocyte chemotaxis | ||
| immune response |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of transport [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| obsolete extracellular space |
|
|
| cytoplasm |
| GO Term | Evidence Code | Reference |
|---|---|---|
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity | ||
| tumor necrosis factor receptor binding | ||
| tumor necrosis factor receptor binding |
GO Hierarchy
Sequence
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | Homo sapiens |
| TNFR2 non-canonical NF-kB pathway | Homo sapiens |
| TNFs bind their physiological receptors | Homo sapiens |
| Transcriptional and post-translational regulation of MITF-M expression and activity | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11476 | osteoporosis | |
| DOID:0110943 | autosomal recessive osteopetrosis 2 |
