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ASH2 like, histone lysine methyltransferase complex subunit

Summary

Gene Symbol

ASH2L

Organism

Homo sapiens (human)

External Links

NCBI Gene

9070

KEGG Gene ID

PubChem

9070

Alliance of Genome Resources

HGNC:744

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromatin regulator
DNA-binding
Methylation
Methyltransferase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription regulation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DPT1
F5H8F7
Q9UBL3	ASH2-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cellular response to DNA damage stimulus	IDA
DNA damage response	IDA
positive regulation of cell population proliferation	IMP
regulation of gene expression	IEA
hemopoiesis	NAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

methylation

cellular developmental process [inference]

cell development [inference]

hemopoiesis

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis

cellular developmental process [inference]

cell development [inference]

hemopoiesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to hormone [inference]

response to estrogen

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

epigenetic regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of gene expression, epigenetic [inference]

transcription initiation-coupled chromatin remodeling

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IMP
nucleus	IEA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

histone methyltransferase complex

MLL1/2 complex

MLL1 complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex

MLL1/2 complex

MLL1 complex

cellular anatomical structure [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
transcription cis-regulatory region binding	IDA
transcription cis-regulatory region binding	IBA
protein binding	IPI
beta-catenin binding	IPI
methyltransferase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding

protein binding

beta-catenin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ASH2

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
obsolete histone H3-K4 methylation

Displaying **all 5** entries
InterPro
B30.2/SPRY domain superfamily
B30.2/SPRY domain
Concanavalin A-like lectin/glucanase domain superfamily
Histone methyltransferase complex subunit ASH2
SPRY domain