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MIRAGE
glyoxylate and hydroxypyruvate reductase
Summary
- Gene Symbol
-
- GRHPR
- Aliases
-
- PH2
- primary hyperoxaluria type 2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- NADP
- Oxidoreductase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9UBQ7 |
|
| A0A384N605 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| carboxylic acid metabolic process |
|
|
| monocarboxylic acid metabolic process |
|
|
| dicarboxylic acid metabolic process |
|
|
| glyoxylate metabolic process |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm |
|
|
| mitochondrion |
|
|
| peroxisomal matrix |
|
|
| cytosol |
|
|
| extracellular exosome |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| glyoxylate reductase (NADPH) activity |
|
|
| carboxylic acid binding |
|
|
| protein homodimerization activity |
|
|
| NADP binding |
|
|
| NAD binding |
|
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111671 | primary hyperoxaluria type 2 | |
| DOID:2977 | primary hyperoxaluria |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000083 | Renal insufficiency |
| HP:0000121 | Nephrocalcinosis |
| HP:0000787 | Nephrolithiasis |
| HP:0000790 | Hematuria |
| HP:0003159 | Hyperoxaluria |
| HP:0006000 | Ureteral obstruction |
| HP:0008672 | Calcium oxalate nephrolithiasis |
| Disease ID | Disease Name |
|---|---|
| OMIM:260000 |
|
| ORPHA:93599 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources |
|---|---|---|
| 76238 | MGI:1923488 |
