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gamma-aminobutyric acid type B receptor subunit 2

Summary

Gene Symbol

GABBR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9568

PubChem

9568

Alliance of Genome Resources

HGNC:4507

Annotation

Keyword

3D-structure
Cell membrane
Coiled coil
Direct protein sequencing
Disease variant
Disulfide bond
Epilepsy
G-protein coupled receptor
Glycoprotein
Intellectual disability
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O75899	G-protein coupled receptor 51 HG20
H9NIL8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS	9872316
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	987231
negative regulation of adenylate cyclase activity	TAS	10328880
gamma-aminobutyric acid signaling pathway	IDA	987231 9872316
gamma-aminobutyric acid signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, GABAergic

neuron-glial cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, GABAergic

neuron-glial cell signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA	15304491 9872316
G protein-coupled receptor heterodimeric complex	IBA
G protein-coupled receptor heterodimeric complex	IPI	9872316

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

GABA receptor complex

G protein-coupled GABA receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IBA
G protein-coupled GABA receptor activity	IDA	9872316
protein binding	IPI	16724110 24305054 24658140 32555460 32580208 32581365 37207277
protein heterodimerization activity	IPI	15304491

GO Hierarchy

molecular function

binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled GABA receptor activity

GABA receptor activity [inference]

G protein-coupled GABA receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
G protein-coupled GABA receptor activity
gamma-aminobutyric acid signaling pathway

Displaying **all 4** entries
InterPro
GPCR family 3, C-terminal
GPCR family 3, GABA-B receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0080291	developmental and epileptic encephalopathy 59	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 55 in total

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Species	Gene ID	Orthologous MAtrix
Mustela putorius furo	101690704	MUSPF15526
Ictidomys tridecemlineatus	101962580	ICTTR00656
Chinchilla lanigera	102017341	CHILA06669
Capra hircus	102186689	CAPHI29186
Astyanax mexicanus	103026663	ASTMX12258
Callorhinchus milii	103186359	CALMI34453
Chlorocebus sabaeus	103219146	CHLSB03194
Nannospalax galili	103748349	NANGA25891
Rhinopithecus roxellana	104657770	RHIRO15788
Macaca nemestrina	105477203	MACNE18047

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements