G00672PE

Summary
GlyTouCan ID
G00672PE
IUPAC Condensed
Neu5Ac(a2-3)Gal6S(b1-4)[Fuc(a1-3)]GlcNAc(b1-
Motifs
6O-Sulfo-sialyl Lewis x 6O-sulfo SLex
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
900.25
GlyGen
ChEBI
PubChem Compound
PubChem Substance
GlycoEpitope
Epitope ID
EP0014
Epitope Name
6'-Sulfo Sialyl Lewis x
Sequence Descriptors
GlycoCT
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
6s:n-acetyl
7s:sulfate
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(3+2)5d
5:5d(5+1)6n
6:4o(6+1)7n
WURCS
WURCS=2.0/4,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5][a2112h-1b_1-5_6*OSO/3=O/3=O][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-4/a3-b1_a4-c1_c3-d2
Literature
Displaying entries 1 - 10 of 28 in total
PubMed ID Title First Author Publication Date Source
9398638 missing tag=TI author information missing missing tag=DP
  • GlyGen
  • GlycoEpitope
27357658 Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8 Pröpster JM 2016 Jun 29
  • PubChem
14593101 Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing Hiraoka N 2004 Jan 23
  • GlyGen
  • GlycoEpitope
15175329 N-Acetylglucosamine 6-O-Sulfotransferase-1 Regulates Expression of L-Selectin Ligands and Lymphocyte Homing Uchimura K 2004 Aug 13
  • GlyGen
  • GlycoEpitope
14568956 Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion Cai S 2003 Nov 01
  • GlyGen
  • GlycoEpitope
12889478 Endoglycan, a Member of the CD34 Family, Functions as an L-selectin Ligand through Modification with Tyrosine Sulfation and Sialyl Lewis x Fieger CB 2003 Jul 25
  • GlyGen
  • GlycoEpitope
12385579 Increased expression of sialyl Lewis(x) antigen in penetrating growth type A early gastric cancer Nakagoe T 2002 Sep
  • GlyGen
  • GlycoEpitope
11919403 High Endothelial Venule-Like Vessels in the Interstitial Lesions of Human Glomerulonephritis Takaeda M 2002 Jan
  • GlyGen
  • GlycoEpitope
12163379 Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites Renkonen J 2002 Aug
  • GlyGen
  • GlycoEpitope
11520459 Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes Hemmerich S 2001 Aug
  • GlyGen
  • GlycoEpitope
PubAnnotation
Displaying entries 1 - 5 of 10 in total
Title Authors Source Publication Date PubMed ID
Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing.
  • Hirakawa J
  • Tsuboi K
  • Sato K
  • Kobayashi M
  • Watanabe S
  • Takakura A
  • Imai Y
  • Ito Y
  • Fukuda M
  • Kawashima H
J Biol Chem 2010 Dec 24 20929857
Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.
  • Kobayashi M
  • Lee H
  • Nakayama J
  • Fukuda M
Glycobiology 2009 May 19150806
Salivary MUC7 is a major carrier of blood group I type O-linked oligosaccharides serving as the scaffold for sialyl Lewis x.
  • Karlsson NG
  • Thomsson KA
Glycobiology 2009 Mar 19043084
Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x.
  • Klopocki AG
  • Yago T
  • Mehta P
  • Yang J
  • Wu T
  • Leppänen A
  • Bovin NV
  • Cummings RD
  • Zhu C
  • McEver RP
J Biol Chem 2008 Apr 25 18250165
Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing.
  • Hiraoka N
  • Petryniak B
  • Kawashima H
  • Mitoma J
  • Akama TO
  • Fukuda MN
  • Lowe JB
  • Fukuda M
Glycobiology 2007 Mar 17172261

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