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G49108TO

Summary

GlyTouCan ID: G49108TO
IUPAC Condensed: GlcNAc(b1-

External Links

GlyConnect structure

8849

GlyGen

G49108TO

ChEBI

28009

PubChem Compound

24139

PubChem Substance

252288111

The Human Metabolome Database

HMDB0000803

3D Structures

GlycoNAVI: G49108TO
GLYCAM: DGlcpNAcb1-OH

GlycoShape

G49108TO

Displaying 1 entry
Archetype	α	β
G14843DJ	G68544GH	G49108TO

Organisms

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Organisms	Evidence
Mus musculus (house mouse)	GlyConnectStructure GlyGen(OGlcNAcAtlas) GlyGen(OGlcNAcDB) GlyGen(UniCarbKB) GlycoEpitope
Rattus norvegicus (Norway rat)	GlyConnectStructure GlyGen(OGlcNAcAtlas) GlyGen(OGlcNAcDB) GlyGen(UniCarbKB) GlycoEpitope
Homo sapiens (human)	GlyConnectStructure GlyGen(OGlcNAcAtlas) GlyGen(OGlcNAcDB) GlyGen(UniCarbKB) GlyTouCan(glycome-db) GlycoEpitope
Drosophila melanogaster (fruit fly)	GlyGen(OGlcNAcDB)
Streptococcus pneumoniae	GlyTouCan(bcsdb)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus [inference]

Rattus norvegicus (Norway rat)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Protostomia [inference]

Ecdysozoa [inference]

Panarthropoda [inference]

Arthropoda (arthropods) [inference]

Mandibulata [inference]

Pancrustacea [inference]

Hexapoda (hexapods) [inference]

Insecta (insects) [inference]

Dicondylia [inference]

Pterygota (winged insects) [inference]

Neoptera [inference]

Endopterygota [inference]

Diptera (flies) [inference]

Brachycera [inference]

Muscomorpha [inference]

Eremoneura [inference]

Cyclorrhapha [inference]

Schizophora [inference]

Acalyptratae [inference]

Ephydroidea [inference]

Drosophilidae (pomace flies) [inference]

Drosophilinae [inference]

Drosophilini [inference]

Drosophila (fruit flies) [inference]

Sophophora [inference]

melanogaster group [inference]

melanogaster subgroup [inference]

Drosophila melanogaster (fruit fly)

Fungi [inference]

Dikarya [inference]

Ascomycota (ascomycetes) [inference]

saccharomyceta [inference]

Saccharomycotina (true yeasts) [inference]

Saccharomycetes [inference]

Saccharomycetales [inference]

Saccharomycetaceae [inference]

Saccharomyces [inference]

Saccharomyces cerevisiae (brewer's yeast)

Bacteria (eubacteria) [inference]

Terrabacteria group [inference]

Bacillota [inference]

Bacilli [inference]

Lactobacillales [inference]

Streptococcaceae [inference]

Streptococcus [inference]

Streptococcus pneumoniae

Viruses [inference]

Riboviria [inference]

Orthornavirae [inference]

Negarnaviricota [inference]

Polyploviricotina [inference]

Insthoviricetes [inference]

Articulavirales [inference]

Orthomyxoviridae [inference]

unclassified Orthomyxoviridae [inference]

unidentified influenza virus

GlycoGene Database (GGDB)

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
B4GALT5	(not applicable)	G49108TO	[beta]-S-pNP	G00055MO	[beta]-S-pNP	9435216
B3GALT2	UDP-Gal	G49108TO	Lemieux	G00056MO	Lemieux	9417100
B4GALT2	UDP-Gal	G49108TO	Benzyl-[beta]	G00055MO	Benzyl-[beta]	9405390
B4GALT1	UDP-Gal	G49108TO	R	G00055MO	R	3014508
B3GALT5	UDP-Gal	G49108TO	R	G00056MO	R	10212226

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
B4GALT5	(not applicable)	G49108TO	[beta]-S-pNP	G00055MO	[beta]-S-pNP	9435216
B4GALT3	UDP-Gal	G49108TO	Benzyl-[beta]	G00055MO	Benzyl-[beta]	9405390
B4GALT4	UDP-Gal	G49108TO	[beta]-1-Benzl	G00055MO	[beta]-1-Benzl	9792633
B3GALT2	UDP-Gal	G49108TO	Lemieux	G00056MO	Lemieux	9417100
B4GALT4	UDP-Gal	G49108TO	[beta]-1-4-methyl-umbelliferyl	G00055MO	[beta]-1-4-methyl-umbelliferyl	9792633

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST6GAL2	CMP-Neu5Ac	G49108TO	para-nitrophenol	12603328
ST6GALNAC2	CMP-Neu5Ac	G49108TO	benzyl	11062056
ST6GAL1	CMP-Neu5Ac	G49108TO	para-nitrophenol	12603328
CHST7	PAPS	G49108TO	-O-CH3	10781596
CHST3	PAPS	G49108TO	-O-CH3	10781596

KEGG BRITE Database

KEGG ID

Enzyme

2.4.1.255

Core Protein

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UniProt ID	Protein Name	Reference	Source
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	29351928	The O-GlcNAc Database
Q9Y4G6	Talin-2	30379171 31637018	GlyGen The O-GlcNAc Database
Q9Y4G8	Rap guanine nucleotide exchange factor 2	28657654 29237092 29351928 30059200 30620550 31492838 35254053 39302247 39531497	GlyGen The O-GlcNAc Database
Q9Y4H2	Insulin receptor substrate 2	23301498 30059200 31373491 32798372 35254053 35289036 36240223 37217939	GlyGen The O-GlcNAc Database
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	29351928 30379171 31492838 34019948 35132862 35254053 38253038 38665916 39302247 39531497 39534244	GlyGen The O-GlcNAc Database
Q9Y4L1	Hypoxia up-regulated protein 1	21526146 22661428 29249144 30059200 30397120 30444036 30620550 32119511 33214551 33465208 34019948 34229054 34725712 35008409 35132862 35138101 35254053 37217939 38665916 39531497 39534244	GlyGen The O-GlcNAc Database
Q9Y4R7	Tubulin monoglycylase TTLL3	30620550	GlyGen The O-GlcNAc Database
Q9Y4W2	Ribosomal biogenesis protein LAS1L	23301498 28510447 30379171 32522876 35083852	GlyGen The O-GlcNAc Database
Q9Y512	Sorting and assembly machinery component 50 homolog	28411811 28510447 33465208 35254053	GlyGen The O-GlcNAc Database
Q9Y520	Protein PRRC2C	20068230 20305658 21740066 22661428 23301498 27114449 27655845 28314751 28510447 28657654 29237092 29351928 30059200 30379171 30620550 31373491 31492838 32119511 32574038 32870666 33214551 34019948 34229054 34725712 34931806 35132862 35138101 35254053 35289036 37340703 38253038 38665916 39302247 39531497 39534244	GlyGen The O-GlcNAc Database GlyConnect

GlycoEpitope

Epitope ID: EP0004

Pathway

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Pathway Name	Organism
Antimicrobial peptides	Drosophila melanogaster
Antimicrobial peptides	Rattus norvegicus
Antimicrobial peptides	Danio rerio
Antimicrobial peptides	Xenopus tropicalis
Antimicrobial peptides	Gallus gallus
Antimicrobial peptides	Homo sapiens
Antimicrobial peptides	Canis familiaris
Antimicrobial peptides	Dictyostelium discoideum
Antimicrobial peptides	Bos taurus
Antimicrobial peptides	Mus musculus

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
LIN
1:1d(2+1)2n

WURCS

WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/

Literature

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PubMed ID	Title	First Author	Publication Date	Source
37945229	Molecular mechanism of Osthole against chitin synthesis of Ustilaginoidea virens based on combined transcriptome and metabolome analyses	Hu X	2023 Nov	PubChem
37595808	Two-stage process production of microbial lipid by co-fermentation of glucose and N-acetylglucosamine from food wastes with Cryptococcus curvatus	Zhang JX	2023 Nov	PubChem
37820866	Growing and dividing: how O-GlcNAcylation leads the way	Saunders H	2023 Nov	PubChem
36963488	Exploration of O-GlcNAc transferase glycosylation sites reveals a target sequence compositional bias	Chong P Andrew	2023 May	GlyGen PubChem
37083327	Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence	Hastie KM	2023 May 30	PubChem
37231419	Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer	Ayodeji SA	2023 May 25	GlyGen PubChem
37225434	Ogt Deficiency Induces Abnormal Cerebellar Function and Behavioral Deficits of Adult Mice through Modulating RhoA/ROCK Signaling	Zhang J	2023 May 24	GlyGen PubChem
37217939	Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis	Hung YW	2023 May 22	GlyGen PubChem
37218374	O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression	Lv Z	2023 May 22	GlyGen PubChem
37205763	Structure of the immunoregulatory sialidase NEU1	Gorelik A	2023 May 19	PubChem

PubAnnotation

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Title	Authors	Source	Publication Date	PubMed ID
Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis.	Sekine O Love DC Rubenstein DS Hanover JA	J Biol Chem	2010 Dec 3	20926386
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.	Wells L Gao Y Mahoney JA Vosseller K Chen C Rosen A Hart GW	J Biol Chem	2002 Jan 18	11788610
Increased N-acetyl-beta-glucosaminidase activity in primary breast carcinomas corresponds to a decrease in N-acetylglucosamine containing proteins.	Slawson C Pidala J Potter R	Biochim Biophys Acta	2001 Sep 28	11566258
Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain.	Murphy JE Hanover JA Froehlich M DuBois G Keen JH	J Biol Chem	1994 Aug 19	8063760

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Guidelines

Summary

External Links

KEGG BRITE Database

GlycoEpitope

Sequence Descriptors

International Collaboration

Acknowledgements