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beta-1,4-galactosyltransferase 2

Summary

Gene Symbol

B4GALT2

Aliases

Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
N-acetyllactosamine synthase
beta4Gal-T2
lactose synthase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

8704

GGDB ID

gg078

HGNC

925

mRNA

NM_003780

map

1p34-p33

Protein

NP_003771

OMIM

604013

KEGG Gene ID

hsa:8704

PubChem

8704

Alliance of Genome Resources

HGNC:925

JoGo

B4GALT2

TogoVar

B4GALT2

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60909	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
memory
locomotory behavior
visual learning
cerebellar Purkinje cell layer development

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

developmental process [inference]

anatomical structure development [inference]

cerebellar Purkinje cell layer development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
nucleoplasm
Golgi apparatus	IDA
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	EXP
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA
N-acetyllactosamine synthase activity	EXP
N-acetyllactosamine synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000117411

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg078

Gene Symbol

B4GALT2

Reactions

Displaying **all 3** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G49108TO	Benzyl-[beta]	G00055MO	Benzyl-[beta]	9405390
UDP-Gal	G76294XX	O(CH2)8COOCH2-mNP	G80524SB	O(CH2)8COOCH2-mNP	9435216
UDP-Gal	G71817IG	O(CH2)8COOCH2-mNP	G81756OO	O(CH2)8COOCH2-mNP	9435216

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G49108TO	[beta]-S-pNP	G00055MO	[beta]-S-pNP	9435216
UDP-Gal	G49108TO	Benzyl-[beta]	G00055MO	Benzyl-[beta]	9405390
UDP-Gal	G76294XX	O(CH2)8COOCH2-mNP	G80524SB	O(CH2)8COOCH2-mNP	9435216
UDP-Gal	G71817IG	O(CH2)8COOCH2-mNP	G81756OO	O(CH2)8COOCH2-mNP	9435216
UDP-Gal	G87229LF	O(CH2)8COOCH2-mNP	G50361AJ	O(CH2)8COOCH2-mNP	9435216

Displaying entries **1 - 5** of 12 in total

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G68544GH	Benzyl-[alpha]	9405390
UDP-Gal	G65889KE	4-Me-lumbelyl-[beta]	9405390
UDP-Gal	G65889KE	o-Nitrophenyl-[beta]	9405390
UDP-Gal	G49108TO		9405390
UDP-Gal	G57321FI	Benzyl-[alpha]	9405390

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Mus musculus	NP_059073	NM_017377
Drosophila melanogaster	NP_610946	NM_137102
Rattus norvegicus	XP_242992	XM_242992

KEGG BRITE Database

Orthology

K07967

Name

beta-1,4-galactosyltransferase 2 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

11588157

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ
R05989	2.4.1.38	G80858MF	G78059CC

Rhea

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002947
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	53418	MGI:1858493
Rattus norvegicus	313536	RGD:1305358
Caenorhabditis elegans	190668	WB:WBGene00000269
Drosophila melanogaster	36585	FB:FBgn0027538
Danio rerio	100148828	ZFIN:ZDB-GENE-070912-258
Xenopus laevis	100190782	Xenbase:XB-GENE-6021325
Xenopus laevis	108714282	Xenbase:XB-GENE-17340339
Xenopus tropicalis	100492356	Xenbase:XB-GENE-997913

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements