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G98544DH

Summary

GlyTouCan ID: G98544DH
IUPAC Condensed: Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-4)Glc(b1-
Motifs: 9-O-Acetyl GD3 GD3
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 924.31

External Links

GlyGen

G98544DH

ChEBI

59210

PubChem Compound

45266862

PubChem Substance

252288444

GlycoShape

Displaying 1 entry
Archetype	α	β
G10158SF	G58409WK	G98544DH

3D Structures

GlycoShape: G98544DH
GLYCAM: Neup5Aca2-8Neup5Aca2-3DGalpb1-4DGlcpb1-OH

Organisms

Displaying entries **1 - 5** of 24 in total

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Organisms	Evidence
Macaca mulatta (Rhesus monkey)	GlyTouCan(glycome-db)
Chinchilla	GlyTouCan(glycome-db)
Macaca fuscata (Japanese macaque)	GlyTouCan(glycome-db)
Galliformes (landfowls)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Chondrichthyes (cartilaginous fishes) [inference]

Elasmobranchii (elasmobranchs) [inference]

Batoidea (rays) [inference]

Rajiformes (skates) [inference]

Rajidae (hardnose skates) [inference]

Leucoraja [inference]

Leucoraja erinacea (little skate)

Torpediniformes [inference]

Torpedinidae (electric rays) [inference]

Torpedo [inference]

Torpedo marmorata (marbled electric ray)

Narcinidae (numbfishes) [inference]

Discopyge [inference]

Discopyge tschudii (apron ray)

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Whippomorpha [inference]

Cetacea (whales) [inference]

Mysticeti (baleen whales) [inference]

Balaenopteridae (rorquals) [inference]

Balaenoptera [inference]

Balaenoptera edeni (pygmy Bryde's whale)

Carnivora (carnivores) [inference]

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Feliformia [inference]

Felidae (cat family) [inference]

Felinae [inference]

Felis [inference]

Felis catus (domestic cat)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Rodentia (rodent) [inference]

Hystricomorpha (guinea pigs and others) [inference]

Chinchillidae (chinchillas)

Chinchilla

Caviidae (cavies) [inference]

Cavia (guinea pigs) [inference]

Cavia porcellus (domestic guinea pig)

Myomorpha (mice and others) [inference]

Muroidea [inference]

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus

Cricetidae [inference]

Cricetinae (hamsters)

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Macaca (macaques) [inference]

Papio (baboons) [inference]

Papio hamadryas (hamadryas baboon)

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Sauropsida (sauropsids) [inference]

Sauria (diapsids) [inference]

Archelosauria [inference]

Archosauria [inference]

Dinosauria [inference]

Saurischia [inference]

Theropoda [inference]

Coelurosauria [inference]

Aves (birds) [inference]

Neognathae [inference]

Galloanserae [inference]

Galliformes (landfowls)

Phasianidae (turkeys) [inference]

Phasianinae [inference]

Gallus [inference]

Gallus gallus (chicken)

Amphibia (amphibians) [inference]

Batrachia [inference]

Anura (frogs and toads) [inference]

Pipoidea [inference]

Pipidae (tongueless frogs) [inference]

Xenopodinae [inference]

Xenopus

Actinopterygii (ray-finned fishes) [inference]

Actinopteri [inference]

Neopterygii [inference]

Teleostei (teleost fishes) [inference]

Osteoglossocephalai [inference]

Clupeocephala [inference]

Otomorpha [inference]

Ostariophysi [inference]

Otophysi [inference]

Cypriniphysae [inference]

Cypriniformes (carps and others) [inference]

Cyprinoidei [inference]

Cyprinidae [inference]

Cyprininae [inference]

Carassius [inference]

Carassius auratus (goldfish)

Bacteria (eubacteria) [inference]

Campylobacterota [inference]

Epsilonproteobacteria [inference]

Campylobacterales [inference]

Campylobacteraceae [inference]

Campylobacter [inference]

Campylobacter jejuni

GlycoGene Database (GGDB)

Displaying **all 4** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA6	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	11980897
ST8SIA1	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	8195250
ST8SIA5	CMP-Neu5Ac	G98544DH	Cer	G93899SO	Cer	8910600
ST8SIA3	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	7782326

Displaying entries **1 - 5** of 7 in total

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Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
ST8SIA6	CMP-Neu5Ac	G91237TK		G98544DH		11980897
ST8SIA6	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	11980897
ST8SIA1	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	8195250 8910600
ST8SIA5	CMP-Neu5Ac	G98544DH	Cer	G93899SO	Cer	8910600 9199191
ST8SIA3	CMP-Neu5Ac	G91237TK	Cer	G98544DH	Cer	7782326 8910600

Displaying **all 5** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
ST8SIA1	CMP-Neu5Ac	G98544DH	Cer	8910600
ST8SIA2	CMP-Neu5Ac	G98544DH	Cer	7782326
ST8SIA6	CMP-Neu5Ac	G98544DH	Cer	11980897 16120058
B4GALNT2	UDP-GalNAc	G98544DH	Cer	12678917
B3GALNT1	UDP-GalNAc	G98544DH	Cer	10993897

KEGG BRITE Database

KEGG ID

G00113

Enzyme

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05940	2.4.3.8	G91237TK	G98544DH
R05946	2.4.1.92	G98544DH	G02657AK
R05947	2.4.3.8	G98544DH	G93899SO

GlycoEpitope

Epitope ID: EP0062
Epitope Name: N-Acetyl GD3

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
4s:n-acetyl
5b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
6s:n-acetyl
LIN
1:1o(4+1)2d
2:2o(3+2)3d
3:3d(5+1)4n
4:3o(8+2)5d
5:5d(5+1)6n

WURCS

WURCS=2.0/3,4,3/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a4-b1_b3-c2_c8-d2

Literature

Displaying entries **1 - 10** of 48 in total

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PubMed ID	Title	First Author	Publication Date	Source
24130487	A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus	Neu U	2013 Oct 10	PubChem
20231015	Efficient synthesis of 6′-sialyllactose, 6,6′-disialyllactose, and 6′-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224	Drouillard S	2010 Jul 02	PubChem
17936010	Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap	Pikulski M	2007 Dec 01	PubChem
17855742	Sulfatide binding properties of murine and human antiganglioside antibodies	Townson K	2007 Aug 17	GlyGen GlycoEpitope
16458866	Lactones of disialyl lactose: characterisation by NMR and mass spectra	Pan GG	2006 May 01	PubChem
16104015	A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin	Jayaraman S	2005 Mar 15	PubChem
16120058	Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins	Teintenier-Lelièvre M	2005 Dec 06	PubChem
15967512	Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire	Boffey J	2005 Aug	GlyGen GlycoEpitope
15464996	Gangliosides of organ-confined versus metastatic androgen-receptor-negative prostate cancer	Ravindranath MH	2004 Nov 05	GlyGen GlycoEpitope
15223242	Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes	Boffey J	2004 Jul	GlyGen GlycoEpitope

PubAnnotation

Displaying entries **6 - 10** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.	García-Ruiz C Colell A Morales A Calvo M Enrich C Fernández-Checa JC	J Biol Chem	2002 Sep 27	12118012
Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis.	Wang XQ Sun P Paller AS	J Biol Chem	2001 Nov 30	11577096
A synthetic approach to polysialogangliosides containing alpha-sialyl-(2-->8)-sialic acid: total synthesis of ganglioside GD3.	Ishida H Ohta Y Tsukada Y Kiso M Hasegawa A	Carbohydr Res	1993 Aug 17	8370046
Specific staining on thin-layer chromatograms of glycosphingolipids of neolacto series and gangliosides with a terminal N-acetylneuraminyl residue by different procedures with wheat germ agglutinin.	Higashi H Sugii T Kato S	Biochim Biophys Acta	1988 Nov 25	2461740
Proton NMR and fast-atom bombardment mass spectrometry analysis of the melanoma-associated ganglioside 9-O-acetyl-GD3.	Thurin J Herlyn M Hindsgaul O Strömberg N Karlsson KA Elder D Steplewski Z Koprowski H	J Biol Chem	1985 Nov 25	4055789

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