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beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)

Summary

Gene Symbol

B3GALNT1

Aliases

B3GALANT1
GLOB
P antigen synthase
beta3Gal-T3
galT3
globoside synthase

Organism

Homo sapiens (human)

External Links

NCBI Gene

8706

GGDB ID

gg102

HGNC

918

mRNA

NM_003781

map

3q25

Protein

NP_003772

OMIM

603094

KEGG Gene ID

hsa:8706

PubChem

8706

Alliance of Genome Resources

HGNC:918

JoGo

B3GALNT1

TogoVar

B3GALNT1

Annotation

Keyword

Blood group antigen
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Magnesium
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B3KTQ4
Q49AT3
O75752	Beta-1,3-galactosyltransferase 3 Beta-3-Gx-T3 Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase Globoside synthase UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Q7L9G8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein O-linked glycosylation
lipid metabolic process
glycosphingolipid biosynthetic process	TAS
glycoprotein biosynthetic process	IEA
oligosaccharide biosynthetic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

carbohydrate derivative metabolic process

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation

carbohydrate derivative biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IBA
Golgi membrane	IEA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IBA
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IEA
hexosyltransferase activity	IEA
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity	EXP
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity

hexosyltransferase activity

acetylgalactosaminyltransferase activity [inference]

galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg102

Gene Symbol

B3GALNT1

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GalNAc	G00059MO	Cer	G00061MO	Cer	10993897

Displaying **all 4** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GalNAc	G98544DH	Cer	10993897
UDP-GalNAc	G00061MO	Cer	10993897
UDP-GalNAc	G84224TW	Cer	10993897
UDP-GalNAc	G91237TK	Cer	10993897

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_064410	NM_020026
Rattus norvegicus	AAH79206	BC079206

KEGG BRITE Database

Orthology

K00719

Name

galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]

References

10993897

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05962	2.4.1.79	G00059MO	G00061MO
R11378	2.4.1.79	G58896AZ	G32252UW
R11321	2.4.1.79	G78074HX	G57710SU

Rhea

RHEA:22252

a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-α-D-galactosamine

H⁺ + a globoside Gb4Cer (d18:1(4E)) + UDP

Enzyme

2.4.1.79

PMID

Disease

PubChem Disease

MedGen Diseases

OMIM Phenotypes

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002663
Gene Name: beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	26879	MGI:1349405
Rattus norvegicus	310508	RGD:1304797
Caenorhabditis elegans	178142	WB:WBGene00000270
Drosophila melanogaster	246409	FB:FBgn0050037
Drosophila melanogaster	34105	FB:FBgn0031986
Drosophila melanogaster	36279	FB:FBgn0053145
Drosophila melanogaster	31358	FB:FBgn0000221

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements