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G00059MO

Summary

GlyTouCan ID: G00059MO
IUPAC Condensed: Gal(a1-4)Gal(b1-4)Glc(b1-
Motifs: Gb3 Pk antigen globotriaosylceramide
Subsumption Level: Fully-defined saccharide
Monoisotopic Mass: 504.17

External Links

GlyGen

G00059MO

ChEBI

68485

PubChem Compound

5279515

PubChem Substance

252284581

3D Structures

GlycoNAVI: G00059MO
GlycoShape: G00059MO
GLYCAM: DGalpa1-4DGalpb1-4DGlcpb1-OH

Organisms

Displaying entries **1 - 5** of 16 in total

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Organisms	Evidence
Macaca mulatta (Rhesus monkey)	GlyTouCan(glycome-db)
Macaca fuscata (Japanese macaque)	GlyTouCan(glycome-db)
Mus musculus (house mouse)	GlyTouCan(glycome-db)
Gallus gallus (chicken)	GlyTouCan(glycome-db)
Chlorocebus sabaeus (green monkey)	GlyTouCan(glycome-db)

Taxonomic Hierarchy

root

cellular organisms [inference]

Eukaryota (eucaryotes) [inference]

Opisthokonta [inference]

Metazoa (metazoans) [inference]

Eumetazoa [inference]

Bilateria [inference]

Deuterostomia [inference]

Chordata (chordates) [inference]

Craniata [inference]

Vertebrata (vertebrates) [inference]

Gnathostomata (jawed vertebrates) [inference]

Teleostomi [inference]

Euteleostomi (bony vertebrates) [inference]

Sarcopterygii [inference]

Dipnotetrapodomorpha [inference]

Tetrapoda (tetrapods) [inference]

Amniota (amniotes) [inference]

Mammalia (mammals) [inference]

Theria [inference]

Eutheria (placentals) [inference]

Boreoeutheria [inference]

Laurasiatheria [inference]

Artiodactyla (even-toed ungulates & whales) [inference]

Suina [inference]

Suidae (pigs) [inference]

Sus [inference]

Sus scrofa (pig)

Ruminantia [inference]

Pecora [inference]

Bovidae [inference]

Bovinae [inference]

Bos (cattle) [inference]

Bos taurus (domestic cattle)

Caprinae [inference]

Ovis [inference]

Ovis aries (sheep)

Carnivora (carnivores) [inference]

Caniformia [inference]

Canidae (dog, coyote, wolf, fox) [inference]

Canis [inference]

Canis lupus (gray wolf) [inference]

Canis lupus familiaris (dog)

Euarchontoglires [inference]

Glires (Rodents and rabbits) [inference]

Lagomorpha [inference]

Leporidae (rabbits and hares) [inference]

Oryctolagus [inference]

Oryctolagus cuniculus (rabbit)

Rodentia (rodent) [inference]

Myomorpha (mice and others) [inference]

Muroidea [inference]

Cricetidae [inference]

Cricetinae (hamsters)

Muridae [inference]

Murinae [inference]

Mus (mice) [inference]

Mus [inference]

Mus musculus (house mouse)

Rattus

Primates [inference]

Haplorrhini [inference]

Simiiformes [inference]

Catarrhini [inference]

Cercopithecoidea [inference]

Cercopithecidae (Old World monkeys) [inference]

Cercopithecinae [inference]

Macaca (macaques) [inference]

Chlorocebus [inference]

Chlorocebus sabaeus (green monkey)

Hominoidea (apes) [inference]

Hominidae (great apes) [inference]

Homininae [inference]

Homo [inference]

Homo sapiens (human)

Sauropsida (sauropsids) [inference]

Sauria (diapsids) [inference]

Archelosauria [inference]

Archosauria [inference]

Dinosauria [inference]

Saurischia [inference]

Theropoda [inference]

Coelurosauria [inference]

Aves (birds) [inference]

Neognathae [inference]

Galloanserae [inference]

Galliformes (landfowls) [inference]

Phasianidae (turkeys) [inference]

Phasianinae [inference]

Gallus [inference]

Gallus gallus (chicken)

Discoba [inference]

Euglenozoa [inference]

Kinetoplastea (kinetoplasts) [inference]

Metakinetoplastina [inference]

Trypanosomatida [inference]

Trypanosomatidae [inference]

Leishmaniinae [inference]

Leishmania [inference]

Leishmania mexicana species complex [inference]

Leishmania amazonensis

Bacteria (eubacteria) [inference]

Pseudomonadota [inference]

Betaproteobacteria [inference]

Neisseriales [inference]

Neisseriaceae [inference]

Neisseria [inference]

Neisseria gonorrhoeae [inference]

Neisseria gonorrhoeae 1291

Gammaproteobacteria [inference]

Pasteurellales [inference]

Pasteurellaceae [inference]

Haemophilus [inference]

Haemophilus influenzae

GlycoGene Database (GGDB)

Displaying 1 entry
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
A4GALT	UDP-Gal	G84224TW	Cer	G00059MO	Cer	10747952

Displaying **all 2** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
A4GALT	UDP-Gal	G84224TW	Cer	G00059MO	Cer	10747952
B3GALNT1	UDP-GalNAc	G00059MO	Cer	G00061MO	Cer	10993897

Displaying **all 5** entries
Gene Symbol	Donor	Acceptor	Reducing terminal(Acceptor)	Reference
B3GALT1	UDP-Gal	G00059MO	Cer	9582303
B3GALT2	UDP-Gal	G00059MO	Cer	9582303
B4GALT3	UDP-Gal	G00059MO	Cer	9405390
B3GALT4	UDP-Gal	G00059MO	Cer	9582303
B3GALNT2	UDP-GalNAc	G00059MO	Cer	14724282

KEGG BRITE Database

KEGG ID

G00093

Enzyme

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05962	2.4.1.79	G00059MO	G00061MO
R05961	3.2.1.22	G00059MO	G84224TW
R05963	3.2.1.52	G00061MO	G00059MO
R05960	2.4.1.228	G84224TW	G00059MO

GlycoEpitope

Epitope ID: EP0071
Epitope Name: Gb3

Sequence Descriptors

GlycoCT

RES
1b:b-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:a-dgal-HEX-1:5
LIN
1:1o(4+1)2d
2:2o(4+1)3d

WURCS

WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1

Literature (from GlyTouCan)

BCSDB

John CM et al. The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides. J Biol Chem. 1991 Oct 15;266:(29):19303-11. PMID: 1918047.

GlycoEpitope

PubAnnotation

Displaying entries **1 - 5** of 10 in total

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Title	Authors	Source	Publication Date	PubMed ID
Single-mutations at the galactose-binding site of enzymes GalK, GalU, and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-d-galactose and azido-functionalized Gb3 analogs.	Ortiz-Soto ME Baier M Brenner D Timm M Seibel J	Glycobiology	2023 Oct 6	37283491
Combining Mass Spectrometry, Surface Acoustic Wave Interaction Analysis, and Cell Viability Assays for Characterization of Shiga Toxin Subtypes of Pathogenic Escherichia coli Bacteria.	Steil D Pohlentz G Legros N Mormann M Mellmann A Karch H Müthing J	Anal Chem	2018 Aug 7	29939014
Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase.	Kaczmarek R Mikolajewicz K Szymczak K Duk M Majorczyk E Krop-Watorek A Buczkowska A Czerwinski M	Glycoconj J	2016 Dec	27538840
Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.	Ando R Tokuda N Yamamoto T Ikeda K Hashimoto N Taguchi R Fan X Furukawa K Niimura Y Suzuki A Goto M Furukawa K	Glycoconj J	2016 Apr	26883028
Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.	Gupta V Bhinge KN Hosain SB Xiong K Gu X Shi R Ho MY Khoo KH Li SC Li YT Ambudkar SV Jazwinski SM Liu YY	J Biol Chem	2012 Oct 26	22936806

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