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MIRAGE

Cholesterol 25-hydroxylase-like protein 2

Summary

UniProt ID: A8WGT1
Gene Symbol: ch25hl2 zgc:175201
Gene ID: 100136851
Organism: Danio rerio (zebrafish)

External Links

Re-Glyco: A8WGT1

Annotation

Keyword: Endoplasmic reticulum Glycoprotein Iron Metal-binding Monooxygenase Reference proteome Sterol biosynthesis Transmembrane helix

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
cholesterol metabolic process
sterol biosynthetic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

Displaying 1 entry
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
C-4 methylsterol oxidase activity
iron ion binding	IEA	GO_REF
steroid hydroxylase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLDISNTTWDLSNQSVLQPLWDYLQQNHESSLRSPLFPVILSVSMYLVLVFFYTVLDLLAPTWPSIRRYQIHQDRTVTWSNIGSTLALTTYNHLLYIFPAAVAQWLWRPPIPLPREAPTLTAFLLGIVGCTVVFDFQYYLWHLLHHRVGWLYRTFHALHHQYRQTFSLVTQYLSAWELFSVGFWTTVDPLLLQCHCLTAWAFMLFNIWVSTEDHCGYDFPWAMHRLVPFGLWGGALRHDAHHQLPGTNFAPFFAHWDWLGGTATMPAPVKTKKRDDKEA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
6	N-linked (GlcNAc...) asparagine			UniProt
13	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026