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Sulfhydryl oxidase 1

Summary

UniProt ID: O00391
Gene Symbol: QSOX1 QSCN6 UNQ2520/PRO6013 hCG_22650
Gene ID: 5768
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011152

GlyConnect

Sulfhydryl oxidase 1

GlyGen

O00391

PubChem

O00391

The Human Metabolome Database

HMDBP08287

Re-Glyco

O00391

Annotation

Keyword: 3D-structure Alternative splicing Disulfide bond FAD Glycoprotein Golgi apparatus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Secreted Signal Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
protein folding	IBA	GO_REF
negative regulation of macroautophagy	IMP	PMID
extracellular matrix assembly	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

protein folding

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
Golgi membrane	EXP	PMID
Golgi membrane	IDA	PMID PMID
Golgi membrane	IBA	GO_REF
Golgi membrane	IEA	GO_REF
extracellular region	EXP	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
protein disulfide isomerase activity	IDA	PMID PMID
protein disulfide isomerase activity	IBA	GO_REF
flavin-dependent sulfhydryl oxidase activity	IDA	PMID PMID
flavin-dependent sulfhydryl oxidase activity	IBA	GO_REF
flavin-dependent sulfhydryl oxidase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity [inference]

flavin-dependent sulfhydryl oxidase activity

thiol oxidase activity [inference]

flavin-dependent sulfhydryl oxidase activity

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [inference]

thiol oxidase activity [inference]

flavin-dependent sulfhydryl oxidase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein disulfide isomerase activity

protein-disulfide reductase activity [inference]

flavin-dependent sulfhydryl oxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKGHAGHPAA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 28 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
130	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 23090970 24190977 26791533 29391424 29741879 29757379 32125861 37074911	G77582RK G20312EM G56784JY G51413EV G08146BT G22310AV G45395BF G83229XP G71146HJ G75983OB G48414YA G25451PN G87051GH G27058EU G45495MK G84452RH G83460ZZ G42962KI G44215PV G60923RB G23863VK G57818FI G00406II	GlycoProtDB UniProt GlyGen GlyConnect
243	N-linked (GlcNAc...) asparagine	29671580 29757379	G01650EU G23294PN	UniProt GlyGen GlyConnect
272		23584533	G57321FI	GlyGen
276		23584533	G57321FI	GlyGen
277		23584533	G57321FI	GlyGen
281		23584533	G57321FI	GlyGen
282		23584533	G57321FI	GlyGen
286		23584533	G57321FI	GlyGen
289		23584533	G57321FI	GlyGen
488		23584533	G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Neutrophil degranulation	Homo sapiens
Platelet degranulation	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

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Acknowledgements