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Semaphorin-3A

Summary

UniProt ID: O08665
Gene Symbol: SemD Sema3a Semad
Gene ID: 20346
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003043
GlyGen: O08665
PubChem: O08665
RaftProt: O08665
Re-Glyco: O08665

Annotation

Keyword: 3D-structure Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Neurogenesis Reference proteome Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 54 in total

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GO Term	Evidence Code	Reference
neural crest cell migration	IBA	GO_REF
neuron migration	IMP	PMID PMID
regulation of heart rate	IMP	PMID
nervous system development	IGI	PMID
axon guidance	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cell recognition [inference]

neuron recognition [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

trunk neural crest cell migration [inference]

ventral trunk neural crest cell migration

neural crest cell migration involved in autonomic nervous system development

neural crest cell migration involved in sympathetic nervous system development

neuron migration

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

hypothalamus cell migration [inference]

hypothalamic tangential migration using cell-axon interactions [inference]

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

dendrite morphogenesis

dendrite arborization [inference]

basal dendrite arborization

basal dendrite morphogenesis [inference]

basal dendrite arborization

neuron projection arborization [inference]

dendrite arborization [inference]

basal dendrite arborization

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

motor neuron axon guidance

branchiomotor neuron axon guidance

sympathetic neuron projection guidance

neuron projection fasciculation [inference]

axonal fasciculation

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

maintenance of synapse structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

dendrite morphogenesis

dendrite arborization [inference]

basal dendrite arborization

basal dendrite morphogenesis [inference]

basal dendrite arborization

neuron projection arborization [inference]

dendrite arborization [inference]

basal dendrite arborization

anatomical structure arrangement [inference]

cranial nerve structural organization [inference]

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

sympathetic ganglion development

cranial ganglion development [inference]

system development [inference]

nervous system development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

sympathetic neuron projection extension

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of cell migration

positive regulation of neuron migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of neuron migration [inference]

positive regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

positive regulation of developmental process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

positive regulation of multicellular organismal process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

positive regulation of reproductive process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of gonad development [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of male gonad development [inference]

positive regulation of male gonad development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of cell migration

positive regulation of neuron migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

regulation of neuron migration [inference]

positive regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of neuron migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

negative regulation of epithelial cell migration

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of axon extension involved in axon guidance

regulation of reproductive process [inference]

regulation of gonad development [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of male gonad development [inference]

positive regulation of male gonad development

positive regulation of reproductive process [inference]

positive regulation of gonad development [inference]

positive regulation of male gonad development

regulation of biological quality [inference]

regulation of heart rate

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF
extracellular region	HDA	PMID
obsolete extracellular space
plasma membrane	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

glutamatergic synapse

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

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GO Term	Evidence Code	Reference
semaphorin receptor binding	IBA	GO_REF
semaphorin receptor binding	IPI	PMID
semaphorin receptor binding	IEA	GO_REF
neuropilin binding	IBA	GO_REF
neuropilin binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
53	N-linked (GlcNAc...) asparagine	12925274		UniProt GlyGen
125	N-linked (GlcNAc...) asparagine	12925274		UniProt GlyGen
591	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
CRMPs in Sema3A signaling	Mus musculus
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Mus musculus
Sema3A PAK dependent Axon repulsion	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements