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MIRAGE
Forkhead box protein O3
Summary
- UniProt ID
- O43524
- Gene Symbol
- FKHRL1 FOXO3 FOXO3A
- Gene ID
- 2309
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Acetylation Activator Alternative splicing Apoptosis Chromosomal rearrangement Cytoplasm DNA-binding Methylation Mitochondrion outer membrane Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Transcription regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| negative regulation of transcription by RNA polymerase II | ||
| ovulation from ovarian follicle |
|
|
| initiation of primordial ovarian follicle growth |
|
|
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| transcription cis-regulatory region binding | ||
| transcription cis-regulatory region binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO Hierarchy
Sequence
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 284 |
|
|||
| 286 |
|
|||
| 296 |
|
|||
| 404 |
|
|
||
| 411 |
|
|||
| 418 |
|
|||
| 431 |
|
|||
| 475 |
|
|||
| 476 |
|
|||
| 482 |
|
G49108TO
G81295CK
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the nucleus | Homo sapiens |
| Constitutive Signaling by AKT1 E17K in Cancer | Homo sapiens |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Homo sapiens |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Homo sapiens |
| FLT3 Signaling | Homo sapiens |
| FOXO-mediated transcription of cell cycle genes | Homo sapiens |
| FOXO-mediated transcription of cell death genes | Homo sapiens |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | Homo sapiens |
| Interleukin-4 and Interleukin-13 signaling | Homo sapiens |
| MAPK6/MAPK4 signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
