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MAPK6/MAPK4 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5687128

PubChem

R-HSA-5687128

Description

MAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classified as such based on their lack of activation by MAPKK family members. Unlike the conventional MAPK proteins, which contain a Thr-X-Tyr motif in the activation loop, MAPK6 and 4 have a single Ser-Glu-Gly phospho-acceptor motif (reviewed in Coulombe and Meloche, 2007; Cargnello et al, 2011). MAPK6 is also distinct in being an unstable kinase, whose turnover is mediated by ubiquitin-dependent degradation (Coulombe et al, 2003; Coulombe et al, 2004). The biological functions and pathways governing MAPK6 and 4 are not well established. MAPK6 and 4 are phosphorylated downstream of class I p21 activated kinases (PAKs) in a RAC- or CDC42-dependent manner (Deleris et al, 2008; Perander et al, 2008; Deleris et al, 2011; De La Mota-Peynado et al, 2011). One of the only well established substrates of MAPK6 and 4 is MAPKAPK5, which contributes to cell motility by promoting the HSBP1-dependent rearrangement of F-actin (Gerits et al, 2007; Kostenko et al, 2009a; reviewed in Kostenko et al, 2011b). The atypical MAPKs also contribute to cell motility and invasiveness through the NCOA3:ETV4-dependent regulation of MMP gene expression (Long et al, 2012; Yan et al, 2008; Qin et al, 2008). Both of these pathways may be misregulated in human cancers (reviewed in Myant and Sansom, 2011; Kostenko et al, 2012)

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 46 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O14980	Exportin-1	CRM1 XPO1	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O43524	Forkhead box protein O3	FKHRL1 FOXO3 FOXO3A	view
O60229	Kalirin	DUET DUO HAPIP KALRN TRAD	view
O75914	Serine/threonine-protein kinase PAK 3	OPHN3 PAK3	view
P01106	Myc proto-oncogene protein	BHLHE39 MYC	view
P04792	Heat shock protein beta-1	HSP27 HSP28 HSPB1	view

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