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Matrix metalloproteinase-B

Summary

UniProt ID: O44836
Gene Symbol: H19M22.3 zmp-2
Gene ID: 175383
Organism: Caenorhabditis elegans

External Links

Re-Glyco: O44836

Annotation

Keyword: Alternative splicing Cleavage on pair of basic residues Extracellular matrix Glycoprotein Metal-binding Metalloprotease Reference proteome Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
larval development	IMP	PMID
proteolysis	IEA	GO_REF
determination of adult lifespan	IMP	PMID
determination of adult lifespan	IGI	PMID
heat acclimation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

multicellular organism development [inference]

larval development

determination of adult lifespan

post-embryonic development [inference]

larval development

molting cycle process [inference]

ecdysis, collagen and cuticulin-based cuticle

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

larval development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to heat [inference]

heat acclimation

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

heat acclimation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of locomotion [inference]

positive regulation of locomotion

positive regulation of biological process [inference]

positive regulation of locomotion

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular response to heat

positive regulation of response to stimulus [inference]

positive regulation of cellular response to heat

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of cellular response to heat

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to heat [inference]

positive regulation of cellular response to heat

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein oxidation [inference]

negative regulation of protein oxidation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein oxidation [inference]

negative regulation of protein oxidation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular response to heat

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of cellular response to stress [inference]

regulation of cellular response to heat [inference]

positive regulation of cellular response to heat

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

positive regulation of eating behavior

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

Displaying **all 2** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
extracellular matrix	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	IEA	GO_REF
metallopeptidase activity	IMP	PMID
metallopeptidase activity	IEA	GO_REF
zinc ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTKWSPNGNPLSTIYLILSLFTLAHTAPTTQHSRTTTQLRLEDEDGGGGVDEDSIHFVKGQMEKYGYLKGIDHSSPQEFRQALMFFQEVLEVEQTGNVDEMTVEAASKPRCTQTDVRQEQTKRTKRFTLSKRAKWAHASGQSVTLKWYISDYTSDIDRLETRKVVEKAFKLWSSQSYIKNEKKVTLTFQEASSKDEADINILWAEGNHGDEHDFDGANGKIEGNKKENVLAHTFFPGYARPLNGDIHFDDAEDWEIDVDQVGHGSNKRFFPYVLAHEIGHALGLDHSQKADALMHPYYKNVPINEIQLDIDDKCGVIWNYGGASDFCLYVWLMSQIVEAHNSSAQNNHGVGSITSSRTNKKSFKSEGFFLFQLKFPHSTLTHTDDVVMREKDKRSYRGDSKIPKCSSNNSSQRTLAEKKLTLGLHLSEADAKRYTEMVCNFLAGLHMWRTNPNHHASESLEKEYKGVSQEMGTFSGKSIAVRRLIRHAEHQKERSEKGPLDPDYFDDDFFENFFMEYSK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
341	N-linked (GlcNAc...) asparagine			UniProt
408	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Activation of Matrix Metalloproteinases	Caenorhabditis elegans
Basigin interactions	Caenorhabditis elegans
Collagen degradation	Caenorhabditis elegans
Degradation of the extracellular matrix	Caenorhabditis elegans
EGFR Transactivation by Gastrin	Caenorhabditis elegans
EPH-ephrin mediated repulsion of cells	Caenorhabditis elegans
Neutrophil degranulation	Caenorhabditis elegans

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements