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MIRAGE
Integrin beta-3
Summary
- UniProt ID
- O54890
- Gene Symbol
- Itgb3
- Gene ID
- 16416
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003145
- GlyConnect
- GlyGen
- O54890
- PubChem
- O54890
- RaftProt
- O54890
- Re-Glyco
- O54890
Annotation
- Keyword
- 3D-structure Calcium Cell adhesion Cell junction Cell membrane Cell projection Disulfide bond EGF-like domain Glycoprotein Integrin Magnesium Metal-binding Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Repeat Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| positive regulation of endothelial cell proliferation | ||
| positive regulation of endothelial cell proliferation | ||
| positive regulation of cell-matrix adhesion | ||
| positive regulation of leukocyte migration | ||
| positive regulation of leukocyte migration |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| nucleus | ||
| nucleus | ||
| nucleoplasm | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| fibronectin binding | ||
| fibronectin binding | ||
| fibronectin binding | ||
| protease binding | ||
| protease binding |
Sequence
MRAQWPGQLWAALLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDETLSQGSPRCNLKENLLKDNCAPESIEFPVSEAQILEARPLSSKGSGSSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQAIKNPCYNMKNACLPMFGYKHVLTLTDQVSRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVLPNDGHCHIGTDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQEKEQSFTIKPVGFKDSLTVQVTFDCDCACQAFAQPSSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPDACSFKKECVECKKFNRGTLHEENTCSRYCRDDIEQVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDTSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 345 |
|
|
||
| 396 |
|
|||
| 477 |
|
|||
| 584 |
|
|
||
| 679 |
|
G62765YT
G77547TA
G07755XJ
G64527OM
G06110VR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ECM proteoglycans | Mus musculus |
| Elastic fibre formation | Mus musculus |
| Fibrin formation | Mus musculus |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | Mus musculus |
| Integrin cell surface interactions | Mus musculus |
| Integrin signaling | Mus musculus |
| MAP2K and MAPK activation | Mus musculus |
| Molecules associated with elastic fibres | Mus musculus |
| PECAM1 interactions | Mus musculus |
| Platelet degranulation | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060691 | platelet-type bleeding disorder 16 | |
| DOID:2219 | Glanzmann's thrombasthenia |
