GlyCosmos Portal

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Summary

UniProt ID: O60331
Gene Symbol: KIAA0589 PIP5K1C
Gene ID: 23396
Organism: Homo sapiens (human)

External Links

GlyGen

O60331

PubChem

O60331

SwissLipids

SLP:000000551

The Human Metabolome Database

HMDBP03290

Re-Glyco

O60331

Annotation

Keyword: 3D-structure ATP-binding Acetylation Alternative splicing Cell adhesion Cell junction Cell membrane Cell projection Chemotaxis Cytoplasm Disease variant Endocytosis Exocytosis Kinase Lipid metabolism Methylation Nucleus Phagocytosis Phosphoprotein Proteomics identification Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
phosphatidylinositol biosynthetic process	TAS	Reactome
phagocytosis	TAS	PMID
synaptic vesicle exocytosis	TAS	PMID
actin cytoskeleton organization	TAS	PMID
neutrophil chemotaxis	TAS	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process

biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

phagocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

adherens junction assembly

adherens junction organization [inference]

adherens junction assembly

membrane organization

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

phagocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

phagocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis

establishment of localization in cell [inference]

synaptic vesicle exocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
phagocytic cup	IEA	GO_REF
uropod	TAS	PMID
uropod	IEA	GO_REF
nucleoplasm	IDA	GO_REF
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

uropod

presynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
ATP binding
1-phosphatidylinositol-4-phosphate 5-kinase activity	EXP	PMID PMID
1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS	Reactome Reactome
1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA	GO_REF GO_REF GO_REF
phosphatidylinositol kinase activity	TAS	Reactome

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity

1-phosphatidylinositol-4-phosphate 5-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity

1-phosphatidylinositol-4-phosphate 5-kinase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
472				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Clathrin-mediated endocytosis	Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Homo sapiens
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Homo sapiens
Synthesis of PIPs at the plasma membrane	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060653	lethal congenital contracture syndrome 3	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements