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Synthesis of PIPs at the plasma membrane

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1660499

PubChem

R-HSA-1660499

Description

At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 30 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PIK3CD	view
O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	PIK3C2A	view
O15056	Synaptojanin-2	KIAA0348 SYNJ2	view
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	INPPL1 SHIP2	view
O43426	Synaptojanin-1	KIAA0910 SYNJ1	view
O60331	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	KIAA0589 PIP5K1C	view
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	PIK3C2G	view
P20339	Ras-related protein Rab-5A	RAB5 RAB5A	view
P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PIK3C1 PIK3CB	view
P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	PI5P4KA PIP4K2A PIP5K2 PIP5K2A	view

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