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MIRAGE
Toll-like receptor 5

Summary
UniProt ID
O60602
Gene Symbol
  • TIL3
  • TLR5
Gene ID
7100
Organism
Homo sapiens (human)
GlyGen
O60602
PubChem
O60602
Re-Glyco
O60602
Annotation
Keyword
  • 3D-structure
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Inflammatory response
  • Innate immunity
  • Leucine-rich repeat
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Systemic lupus erythematosus
  • Transmembrane helix
Gene Ontology (GO)
Displaying 1 entry
GO Term
plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
37 N-linked (GlcNAc...) asparagine
46 N-linked (GlcNAc...) asparagine
245 N-linked (GlcNAc...) asparagine
342 N-linked (GlcNAc...) asparagine
422 N-linked (GlcNAc...) asparagine
595 N-linked (GlcNAc...) asparagine
598 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 4 entries
Pathway Name Organism
IRAK4 deficiency (TLR5) Homo sapiens
MyD88 cascade initiated on plasma membrane Homo sapiens
MyD88 deficiency (TLR5) Homo sapiens
Toll Like Receptor 5 (TLR5) Cascade Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:10457 Legionnaires' disease
DOID:1485 cystic fibrosis
DOID:1679 cystitis
DOID:5052 melioidosis
DOID:9074 systemic lupus erythematosus
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025