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MyD88 cascade initiated on plasma membrane

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-975871

PubChem

R-HSA-975871

Description

Mammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of TLR3, can initiate downstream signaling trough MyD88. In the MyD88 - dependent pathway, once the adaptor is bound to TLR it leads to recruitment of IL1 receptor associated kinase family IRAK which is followed by activation of tumour necrosis factor receptor-associated factor 6 (TRAF6) . TRAF6 is an ubiquitin E3 ligase which in turn induces TGF-beta activating kinase 1 (TAK1) auto phosphorylation. Once activated TAK1 can ultimately mediate the induction of the transcription factor NF-kB or the mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60602	Toll-like receptor 5	TIL3 TLR5	view
P51617	Interleukin-1 receptor-associated kinase 1	IRAK IRAK1	view
Q13233	Mitogen-activated protein kinase kinase kinase 1	MAP3K1 MAPKKK1 MEKK MEKK1	view
Q99836	Myeloid differentiation primary response protein MyD88	MYD88	view
Q9BXR5	Toll-like receptor 10	TLR10 UNQ315/PRO358	view
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	IRAK4	view

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