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MIRAGE
Toll-like receptor 2

Summary
UniProt ID
O60603
Gene Symbol
  • TIL4
  • TLR2
Gene ID
7097
Organism
Homo sapiens (human)
GlyConnect
GlyGen
O60603
PubChem
O60603
The Human Metabolome Database
HMDBP12412
Re-Glyco
O60603
Annotation
Keyword
  • 3D-structure
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Inflammatory response
  • Innate immunity
  • Isopeptide bond
  • Leucine-rich repeat
  • NAD
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Gene Ontology (GO)
Displaying entries 1 - 10 of 12 in total
GO Term
secretory granule membrane
cell projection
receptor complex
cell body
Golgi apparatus
cell surface
membrane raft
phagocytic vesicle membrane
Toll-like receptor 1-Toll-like receptor 2 protein complex
Toll-like receptor 2-Toll-like receptor 6 protein complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
114 N-linked (GlcNAc...) asparagine
199 N-linked (GlcNAc...) asparagine
414 N-linked (GlcNAc...) asparagine
442 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 11 - 12 of 12 in total
Pathway Name Organism
Toll Like Receptor TLR1:TLR2 Cascade Homo sapiens
Toll Like Receptor TLR6:TLR2 Cascade Homo sapiens
Disease
Displaying entries 21 - 23 of 23 in total
DO ID Disease Name Source
DOID:8741 seborrheic dermatitis
DOID:9256 colorectal cancer
DOID:9744 type 1 diabetes mellitus
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025