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Toll Like Receptor TLR1:TLR2 Cascade

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-168179

PubChem

R-HSA-168179

Description

TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60603	Toll-like receptor 2	TIL4 TLR2	view
P08571	Monocyte differentiation antigen CD14	CD14	view
P35247	Pulmonary surfactant-associated protein D	COLEC7 PSPD SFTP4 SFTPD	view
Q15399	Toll-like receptor 1	KIAA0012 TLR1	view
Q8IWL1	Pulmonary surfactant-associated protein A2	COLEC5 PSAP SFTP1 SFTPA SFTPA2 SFTPA2B	view
Q8IWL2	Pulmonary surfactant-associated protein A1	COLEC4 PSAP SFTP1 SFTPA SFTPA1 SFTPA1B	view

Displaying **all 3** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_001020	Q8IWL2	Pulmonary surfactant-associated protein A1	view
GL_001021	Q8IWL1	Pulmonary surfactant-associated protein A2	view
GL_001022	P35247	Pulmonary surfactant-associated protein D	view

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