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Phospholipid hydroperoxide glutathione peroxidase GPX4

Summary

UniProt ID

O70325

Gene Symbol

Gpx4

Gene ID

625249

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003175
GlyGen: O70325
PubChem: O70325
RaftProt: O70325
Re-Glyco: O70325

Annotation

Keyword

3D-structure
Alternative initiation
Alternative splicing
Cytoplasm
Developmental protein
Lipid metabolism
Mitochondrion
Nucleus
Peroxidase
Phosphoprotein
Reference proteome
Selenocysteine
Transit peptide

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
nucleus
nuclear envelope
mitochondrion
mitochondrial inner membrane
protein-containing complex
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 13 in total

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GO Term
chromatin organization
response to oxidative stress
arachidonic acid metabolic process
cerebellum development
response to estradiol
response to lipopolysaccharide
dendrite development
multicellular organism growth
protein polymerization
apoptotic process

Displaying **all 4** entries
GO Term
selenium binding
identical protein binding
glutathione peroxidase activity
phospholipid-hydroperoxide glutathione peroxidase activity

Annotation information from UniProt.

Sequence

MSWGRLSRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVCLDKYRGFVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNQEIKEFAAGYNVKFDMYSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
79			G80920RR	GlycoProtDB GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Biosynthesis of D-series resolvins	Mus musculus
Biosynthesis of E-series 18(R)-resolvins	Mus musculus
Biosynthesis of E-series 18(S)-resolvins	Mus musculus
Biosynthesis of aspirin-triggered D-series resolvins	Mus musculus
Synthesis of 12-eicosatetraenoic acid derivatives	Mus musculus
Synthesis of 15-eicosatetraenoic acid derivatives	Mus musculus