GlyCosmos Portal

Submissions

Phospholipid hydroperoxide glutathione peroxidase GPX4

Summary

UniProt ID: O70325
Gene Symbol: GPx4 Gpx4
Gene ID: 625249
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003175
GlyGen: O70325
PubChem: O70325
RaftProt: O70325
Re-Glyco: O70325

Annotation

Keyword: 3D-structure Alternative initiation Alternative splicing Cytoplasm Developmental protein Hydroxylation Lipid metabolism Mitochondrion Nucleus Peroxidase Phosphoprotein Reference proteome Selenocysteine Transit peptide

Gene Ontology (GO)

Displaying entries **6 - 10** of 23 in total

« First

‹ Prev

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	Reference
spermatogenesis	IMP	PMID
dendrite development	IMP	PMID
arachidonate metabolic process	ISS	GO_REF
arachidonate metabolic process	ISO	GO_REF
arachidonate metabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process

olefinic compound metabolic process [inference]

arachidonate metabolic process

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

multicellular organism growth

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to oxygen-containing compound [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

Displaying entries **1 - 5** of 17 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	Reference
nucleus	ISO	GO_REF
nucleus	IDA	PMID
nucleus	IBA	GO_REF
nucleus	IEA	GO_REF
nuclear envelope	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytosol

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
glutathione peroxidase activity	ISO	PMID GO_REF
glutathione peroxidase activity	EXP	PMID
glutathione peroxidase activity	IDA	PMID PMID
glutathione peroxidase activity	IBA	GO_REF
glutathione peroxidase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

selenium binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSWGRLSRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVCLDKYRGFVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNQEIKEFAAGYNVKFDMYSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
79			G80920RR	GlycoProtDB GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Biosynthesis of D-series resolvins	Mus musculus
Biosynthesis of E-series 18(R)-resolvins	Mus musculus
Biosynthesis of E-series 18(S)-resolvins	Mus musculus
Biosynthesis of aspirin-triggered D-series resolvins	Mus musculus
Synthesis of 12-eicosatetraenoic acid derivatives	Mus musculus
Synthesis of 15-eicosatetraenoic acid derivatives	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements