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GlyTouCan
Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
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MIRAGE
Epidermal growth factor receptor
Summary
- UniProt ID
- P00533
- Gene Symbol
-
- EGFR
- ERBB
- ERBB1
- HER1
- Gene ID
- 1956
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011271
- GlyConnect
- GlyGen
- P00533
- PubChem
- P00533
- The Human Metabolome Database
- HMDBP01456
- The O-GlcNAc Database
- P00533
- RaftProt
- P00533
- O-GlcNAcAtlas
- P00533
- Re-Glyco
- P00533
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| nucleus |
| cytoplasm |
| plasma membrane |
| membrane |
| cell junction |
| clathrin-coated endocytic vesicle membrane |
| Shc-EGFR complex |
| multivesicular body, internal vesicle lumen |
| glutamatergic synapse |
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 603 | N-linked (GlcNAc...) asparagine; partial | |||
| 623 | N-linked (GlcNAc...) (high mannose) asparagine | |||
| 816 |
|
|||
| 993 |
|
|
||
| 1043 |
|
|||
| 1044 |
|
|||
|
|
|
G11629QQ
G90382BL
G22310AV
G45395BF
G07246CJ
G08918WF
G00912UN
G78790NZ
G27058EU
G83461WR
G84452RH
G41071NU
G70619PT
G08290VR
G80920RR
G02886BB
G90659AW
G62765YT
G57317CE
G15169WU
G57888GL
G47518TP
G52527GH
G81263BG
G48414YA
G72291OX
G59324HL
G40834TG
G44346CQ
G44490NG
G03754YM
G24271GS
G84330VA
G16933JU
G57581QG
G74859XI
G21737WY
G71560PC
G96914KN
G69834CE
G94531EZ
G40490KT
G92073XL
G07337US
G43665PB
G56784JY
G29501UT
G82140BL
G84543RP
G12728EY
G59590OJ
G65019XG
G79394LC
G86298IX
G11561RV
G51413EV
G65635AB
G17689DH
G01120GS
G70375MX
G84783XD
G04672QB
G16739XK
G08709JB
G66163OV
G85098WU
G07041CT
G22625SJ
G52692IB
G02030ZB
G23340ZN
G57504TA
G13156PQ
G43402RG
G75983OB
G79556AB
G77252PU
G11911BT
G91425YG
G44623TX
G45359RY
G72797UR
G85447US
G44660UQ
G60215UL
G70822IO
G97765TT
G25451PN
G52880ZN
G53752TA
G54505OS
G69982RY
G20425TQ
G79809MM
G06356OH
G45560HM
G23863VK
G78059CC
G40702WU
G64527OM
G05724UK
G68668TB
G83161QT
G39188ZX
G80966KZ
G06110VR
G55220VL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Constitutive Signaling by EGFRvIII | Homo sapiens |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Homo sapiens |
| Downregulation of ERBB2 signaling | Homo sapiens |
| EGFR Transactivation by Gastrin | Homo sapiens |
| EGFR downregulation | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| ERBB2 Activates PTK6 Signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:10283 | prostate cancer | |
| DOID:1324 | lung cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:2957 | pulmonary tuberculosis | |
| DOID:3459 | breast carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma | |
| DOID:4926 | bronchiolo-alveolar adenocarcinoma | |
| DOID:9256 | colorectal cancer |
