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Apolipoprotein A-I

Summary

UniProt ID

P02647

Gene Symbol

APOA1

Organism

Homo sapiens (human)

External Links

GlyGen: P02647
PubChem: P02647
The Human Metabolome Database: HMDBP01620
RaftProt: P02647

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Atherosclerosis
Cholesterol metabolism
Direct protein sequencing
Disease variant
Glycation
HDL
Lipid transport
Neuropathy
Oxidation
Palmitate
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

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GO Term
positive regulation of cholesterol efflux
negative regulation of very-low-density lipoprotein particle remodeling
cholesterol transport
cholesterol efflux
high-density lipoprotein particle clearance
negative chemotaxis
regulation of Cdc42 protein signal transduction
phospholipid efflux
negative regulation of heterotypic cell-cell adhesion
high-density lipoprotein particle remodeling

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GO Term
extracellular space
plasma membrane
endocytic vesicle
cytoplasmic vesicle
collagen-containing extracellular matrix
extracellular exosome
endocytic vesicle lumen
extracellular vesicle
secretory granule lumen

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GO Term
cholesterol transfer activity
identical protein binding
protein homodimerization activity
chemorepellent activity
amyloid-beta binding
phospholipid binding
high-density lipoprotein particle binding
apolipoprotein receptor binding
apolipoprotein A-I receptor binding
high-density lipoprotein particle receptor binding

Annotation information from UniProt.

Sequence

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
220			G57321FI	GlyGen
221			G57321FI	GlyGen
228			G57321FI	GlyGen
263	N-linked (Glc) (glycation) lysine	8261628		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Platelet degranulation	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
Retinoid metabolism and transport	Homo sapiens
Scavenging by Class A Receptors	Homo sapiens
Scavenging by Class B Receptors	Homo sapiens
Scavenging of heme from plasma	Homo sapiens