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Repository for lectin-assisted multimodality data
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MIRAGE
Amyloid-beta precursor protein
Summary
- UniProt ID
- P05067
- Gene Symbol
- APP A4 AD1
- Gene ID
- 351
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011374
- GlyConnect
- GlyGen
- P05067
- PubChem
- P05067
- The Human Metabolome Database
- HMDBP01991
- The O-GlcNAc Database
- P05067
- RaftProt
- P05067
- O-GlcNAcAtlas
- P05067
- Re-Glyco
- P05067
Annotation
- Keyword
- 3D-structure Alternative splicing Alzheimer disease Amyloid Amyloidosis Apoptosis Cell adhesion Cell membrane Cell projection Coated pit Copper Cytoplasm Cytoplasmic vesicle Direct protein sequencing Disease variant Disulfide bond Endocytosis Endoplasmic reticulum Endosome Golgi apparatus Heparin-binding Iron Isopeptide bond Metal-binding Neurodegeneration Notch signaling pathway Nucleus Oxidation Phosphoprotein Proteoglycan Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Sulfation Transmembrane helix Ubl conjugation Zinc
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| microglial cell activation | ||
| microglial cell activation | ||
| astrocyte activation involved in immune response | ||
| regulation of translation | ||
| calcium ion transport |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| DNA binding | ||
| serine-type endopeptidase inhibitor activity | ||
| serine-type endopeptidase inhibitor activity | ||
| signaling receptor binding | ||
| signaling receptor binding |
Sequence
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 22 |
|
|||
| 107 |
|
|||
| 276 |
|
|||
| 279 |
|
|||
| 280 |
|
|||
| 282 |
|
|||
| 352 |
|
|||
| 353 |
|
|||
| 360 |
|
|||
| 364 |
|
G43417UB
G57321FI
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Advanced glycosylation endproduct receptor signaling | Homo sapiens |
| Aggregated β-amyloid induces FXII autocatalysis | Homo sapiens |
| Aggregated β-amyloid interacts with fibrinogen | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Homo sapiens |
| ECM proteoglycans | Homo sapiens |
| Formyl peptide receptors bind formyl peptides and many other ligands | Homo sapiens |
| G alpha (i) signalling events | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:1561 | cognitive disorder | |
| DOID:0070028 | APP-related cerebral amyloid angiopathy | |
| DOID:0081292 | traumatic brain injury | |
| DOID:10652 | Alzheimer's disease |
